122-52-1
Triethyl phosphite
CAS: 122-52-1
Molecular Formula: C6H15O3P
122-52-1 - Names and Identifiers
| Name | Triethyl phosphite |
| Synonyms | (C2H5O)3P TRIETHYLPHOSPHILE Triethyl phosphite fosforyntrojetylowy TRIETHYL PHOSPHITE HP Ethyl phosphite, (EtO)3P Phosphorous acid triethyl Phosphorous acid triethyl ester TRIETHYLPHOSPHITE FOR SYNTHESIS |
| CAS | 122-52-1 |
| EINECS | 204-552-5 |
| InChI | InChI=1/C6H15O3P/c1-4-7-10(8-5-2)9-6-3/h4-6H2,1-3H3 |
122-52-1 - Physico-chemical Properties
| Molecular Formula | C6H15O3P |
| Molar Mass | 166.16 |
| Density | 0.969 g/mL at 25 °C(lit.) |
| Melting Point | -112°C |
| Boling Point | 65 °C |
| Flash Point | 130°F |
| Water Solubility | slightly soluble |
| Appearance | liquid |
| Specific Gravity | 0.969 |
| Color | colorless |
| Odor | characteristic, obnoxious, phosphiteodor |
| BRN | 956578 |
| Storage Condition | Flammables area |
| Sensitive | Air & Moisture Sensitive |
| Explosive Limit | 3.75-42.5%(V) |
| Refractive Index | n20/D 1.413(lit.) |
| Physical and Chemical Properties | Density 0.969 boiling point 156°C refractive index 1.421-1.414 flash point 52°C water-soluble soda solution |
122-52-1 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R10 - Flammable R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2323 3/PG 3 |
| WGK Germany | 1 |
| RTECS | TH1130000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 2920 24 00 |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orl-rat: 1840 mg/kg JACTDZ 1,218,92 |
122-52-1 - Nature
Open Data Verified Data
colorless transparent liquid, special odor, flammable. Relative density (d20) 0.963. Boiling point of 156 deg C; 49 deg C (1. 6kPa). Flash point 54 °c. Refractive index 413. Soluble in ethanol, ether and other organic solvents, insoluble in water. It is easy to gradually hydrolyze to diethyl phosphite in water.
Last Update：2024-01-02 23:10:35
122-52-1 - Preparation Method
Open Data Verified Data
using anhydrous ethanol, phosphorus trichloride and liquid ammonia as raw materials, the esterification reaction was carried out in xylene solvent to generate triethyl phosphite. The crude ester was washed with water to remove ammonium chloride and diethyl phosphite, the product was obtained by distillation.
Last Update：2022-01-01 10:34:03
122-52-1 - Use
Open Data Verified Data
pesticide intermediates, used for the preparation of insecticide versula and other agricultural pesticides. It can also be used as a plasticizer and stabilizer, and as an additive for lubricating grease. Pharmaceutical intermediate, used in the production of analgesic drug benzothiazide.
Last Update：2022-01-01 10:34:02
122-52-1 - Safety
Open Data Verified Data
- This product is toxic. Mouse abdominal LD50>0.5g/kg. Long-term contact can cause tachycardia, dizziness and other phenomena.
- This product is packaged in an iron drum. Store in a cool and dry place and protect with nitrogen. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:34:03
122-52-1 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | triethyl phosphite can be used in the synthesis of pesticide, insecticide and Borer, and is used in the production of analgesics, it can also be used as an additive for plasticizers, stabilizers, lubricating oils and greases. It is used as an intermediate for medicine and pesticide. It is used to produce the analgesic drug benzothiazide, pesticide versula, etc.; It is also used as an additive for plasticizer, stabilizer, lubricating oil and grease. |
| production method | with anhydrous ethanol, phosphorus trichloride and liquid ammonia as raw materials, the esterification reaction is carried out in xylene solvent to produce triethyl phosphite, the crude ester was washed with water to remove ammonium chloride and diethyl phosphite. After distilling off the solvent, the product was obtained by distillation. Raw material consumption quota: phosphorus trichloride (95%)950kg/t, anhydrous ethanol 930kg/t, liquid ammonia 340kg/t. The preparation method is obtained by reacting anhydrous ethanol, phosphorus trichloride and ammonia. 3C2H5OH + PCl3 + NH3 [solvent] →(C2H5O)3P + 3NH4Cl anhydrous ethanol, methyl red indicator and solvent were added to a three-necked flask, and phosphorus trichloride and solvent were stirred in a dropping funnel. With strong stirring, ammonia gas is slowly introduced at about 0 ℃, and phosphorus trichloride is added dropwise at the same time to adjust the speed of the two, so that the reaction solution is red, and the dropping acceleration of the two is gradually increased, the reaction temperature was maintained at 0 to 10 ° C. For about 2H, and the dropwise addition of phosphorus trichloride was completed, and ammonia gas was continued for several minutes to make the reactant alkaline. Water was added to dissolve the by-products ammonium chloride and diethyl phosphite, and the aqueous layer was separated by a separatory funnel. The oil layer was vacuum fractionated to recover the solvent, and then vacuum fractionated to obtain triethyl phosphite. This method is simple, The raw materials are readily available and the cost is low. The solvent is preferably petroleum ether, and xylene, toluene, trichloroethylene and the like can also be used. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 1840 mg/kg; Oral-mouse LD50: 2500 mg/kg |
| stimulation data | Skin-rabbit 500 mg mild; Eye-rabbit 100 mg moderate |
| flammability hazard characteristics | flammable; Toxic phosphorus oxide smoke emitted by heat |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | water mist, carbon dioxide, sand, foam |
| spontaneous combustion temperature | 250°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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