1223404-88-3

1223404-88-3 - Names and Identifiers

Name	(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
Synonyms	Larotrectinib Impurity 5(Larotrectinib DFP-PPPA Impurity) (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine
CAS	1223404-88-3

1223404-88-3 - Physico-chemical Properties

Molecular Formula	C16H15F2N5
Molar Mass	315.3206064
Density	1.50±0.1 g/cm3(Predicted)
pKa	3.14±0.30(Predicted)
Storage Condition	2-8℃

1223404-88-3 - Upstream Downstream Industry

Downstream Products

LOXO-101 (sulfate)

1223404-88-3 - Introduction

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine is (R)-5-(2-(2, 5-Difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine. The intermediate is an organic compound with the following properties:

Appearance: A white solid
Molecular formula: C, H, F, N
Molecular weight: 349.35g/mol

The (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine has the following uses:

1. Drug research and development: As an intermediate of LOXO101 (a pamex inhibitor), it is used to synthesize the drug.

Regarding the preparation method, the preparation of this intermediate is generally divided into a plurality of steps. First, (R)-5-(2-(2,5-difluorophenyl) pyrrolidin-L-yl) pyrrolidone was synthesized by a synthetic reaction, the reaction then reacts with 2-aminopyrrolo [1,5-a] pyrimidin-3-ol to produce the intermediate. Specific synthetic steps need to be designed according to specific chemical synthesis methods.

When using and handling (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine, you need to follow some safety information:

1. Wear personal protective equipment such as gloves and safety glasses when operating.
2. Avoid direct contact with skin, eyes and respiratory tract.
3. When used in a laboratory environment, operate under well-ventilated conditions.
4. When stored in the dark, dry, low temperature preservation.

Last Update：2024-04-09 21:49:45