123653-11-2

Name	NS-398
Synonyms	NS-398 CS-2231 Taisho NS 398 NS-398 (NS 398 N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE
CAS	123653-11-2

Molecular Formula	C13H18N2O5S
Molar Mass	314.36
Density	1.377±0.06 g/cm3(Predicted)
Melting Point	124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boling Point	490.6±55.0 °C(Predicted)
Water Solubility	DMSO: >5 mg/mL
Solubility	DMSO: >5mg/mL
Appearance	solid
Color	off-white
pKa	6.33±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
In vitro study	NS-398 inhibited COX-2 activity in a concentration-dependent manner with an IC50 of 3.8 μm. The NS-398 of 100 μm had no effect on COX-1 activity. NS-398 at 10 μm increased COX-2 and pro-inflammatory cytokine production, induced apoptosis in LNCaP cells, but had no effect in C4-2b cells that did not respond to androgen. C4-2b cells, when treated with NS-398, retain their proliferative and malignant phenotypic characteristics, prompting them to differentiate into neuroendocrine-like cells. Neuroendocrine-like cells produce epithelial and neuronal proteins, and the response of C4-2b cells to NS-398 is regulated by activation of NF-kB transcription factors, NS-398 induced NF-kB signals and down-regulated the expression of ikβ-α protein in LNCaP C4-2b cells.
In vivo study	NS398 can inhibit hearing impairment-induced COX-2 expression and alleviate noise-induced hearing threshold changes and hair cell loss.

Risk Codes	R22 - Harmful if swallowed R24 - Toxic in contact with skin R25 - Toxic if swallowed
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	PB0473500