1236699-92-5
Pimasertib (AS-703026)
CAS: 1236699-92-5
Molecular Formula: C15H15FIN3O3
1236699-92-5 - Names and Identifiers
1236699-92-5 - Physico-chemical Properties
| Molecular Formula | C15H15FIN3O3 |
| Molar Mass | 431.2 |
| Density | 1.769 |
| Boling Point | 623.2±55.0 °C(Predicted) |
| pKa | 12.82±0.46(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | AS703026 is a novel selective, Orally Bioavailable MEK1/2 inhibitor that binds to specific MEK allosteric sites with strong kinase selectivity. AS703026 inhibits the growth and survival of human multiple myeloma cells (including U266 and INA-6 cells) with IC50 of 5 and 11 nM, respectively. Cell cycle arrest in the G0-G1 phase modulates the inhibitory effect of AS703026 and is accompanied by a decrease in the expression of the MAF oncogene. AS703026 acts on MM cells to induce apoptosis by lysing caspase-3 and PARP. AS703026 is effective in the treatment of mutated colorectal cancer. 10 μm AS703026 was effective at inhibiting the ERK pathway, proliferation, and transformation in human colorectal cancer cells carrying the K-Ras (D-MUT) mutant allele. |
| In vivo study | AS703026 at 15 and 30 mg/kg significantly inhibited tumor growth in human plasma cell H929MM xenografts and was associated with down-regulation of pERK1/2, including PARP cleavage, and microtubule decline. 10 mg/kg AS703026 inhibited tumor growth and significantly reduced p-ERK level in human K-Ras mutant (D-MUT) colorectal xenografts. |
1236699-92-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.319 ml | 11.596 ml | 23.191 ml |
| 5 mM | 0.464 ml | 2.319 ml | 4.638 ml |
| 10 mM | 0.232 ml | 1.16 ml | 2.319 ml |
| 5 mM | 0.046 ml | 0.232 ml | 0.464 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Pimasertib (AS-703026) Visit Supplier Webpage Request for quotation
CAS: 1236699-92-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1236699-92-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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