1243389-57-2

Name	6-Bromo-3-chlorobenzo[d]isoxazole
Synonyms	6-bromo-3-chloro-1,2-benzoxazole 6-Bromo-3-chlorobenzo[d]isoxazole 6-Bromo-3-chloro-1,2-benzisoxazole 1,2-Benzisoxazole, 6-bromo-3-chloro-
CAS	1243389-57-2

Molecular Formula	C7H3BrClNO
Molar Mass	232.46
Density	1.820±0.06 g/cm3(Predicted)
Boling Point	313.6±22.0 °C(Predicted)
pKa	-6.79±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

introduction	6-bromo-3-chlorobenzo [D] isoxazole is a pharmaceutical intermediate, there are reports that it can be used to prepare compounds N'-[trans-4-[2-[4-(3-chloro-benzo [d] isoxazole)-6-piperidinyl] ethyl] cyclohexyl]-N,N-dimethylurea for the treatment of neuropsychiatric diseases.
Example application		CN201610643389.0 reported that 6-bromo-3-chlorobenzo [D] isoxazole can be used to prepare compound N'-[trans -4-[2-[4-(3-chlorobenzo [d] isoxazole)-6-piperidinyl] ethyl] cyclohexyl]-N,N-dimethylurea (compound 12). These compounds have D2/D3 antagonist effect and serotonin absorption inhibition effect, as well as anti-schizophrenia effect, increase the broad spectrum of mental illness treatment, reduce side effects.

Last Update：2024-04-09 02:00:03