1246189-43-4
BIS-PEG8-COOH
CAS: 1246189-43-4
Molecular Formula: C20H38O12
1246189-43-4 - Names and Identifiers
1246189-43-4 - Physico-chemical Properties
| Molecular Formula | C20H38O12 |
| Molar Mass | 470.51 |
| Density | 1.179±0.06 g/cm3(Predicted) |
| Boling Point | 601.8±55.0 °C(Predicted) |
| pKa | 3.97±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
1246189-43-4 - Introduction
BIS-PEG8-COOH, fully known as BIS (polyethylene glycol) cyclohexylene-8-carboxylic acid, is a chemical compound. It has the following properties and uses:
Properties: BIS-PEG8-COOH is a white to yellowish solid with good solubility, soluble in water, ethanol and dimethyl sulfoxide. It is a polyethylene glycol derivative modified with a carboxylic acid functional group.
Uses: BIS-PEG8-COOH are commonly used in the fields of biomedicine and medicinal chemistry as a modifier and cross-linking agent. It can be used to prepare polymer materials, nanoparticles and Biomacromolecules to improve solubility, biocompatibility and drug release. In addition, BIS-PEG8-COOH can also be used in biomarkers and immunological research for modifying biomolecules such as proteins, peptides and antibodies.
Preparation method: The method of preparing BIS-PEG8-COOH usually involves a chemical reaction of the polymer. One common method of preparation is to obtain BIS-PEG8-COOH by reacting polyethylene glycol with cyclohexanedianhydride and then carboxylating the resulting esterified product.
Safety information: There is no detailed research data on the safety of BIS-PEG8-COOH. However, polyethylene glycol derivatives generally have good biocompatibility and low toxicity. During operation and use, follow appropriate laboratory safety practices, such as wearing protective gloves, glasses and laboratory clothing, and avoid inhalation, ingestion or contact with skin. If accidental exposure occurs, measures should be taken in a timely manner for cleaning and disposal. Observe local safety guidelines and regulatory requirements when using the BIS-PEG8-COOH.
Properties: BIS-PEG8-COOH is a white to yellowish solid with good solubility, soluble in water, ethanol and dimethyl sulfoxide. It is a polyethylene glycol derivative modified with a carboxylic acid functional group.
Uses: BIS-PEG8-COOH are commonly used in the fields of biomedicine and medicinal chemistry as a modifier and cross-linking agent. It can be used to prepare polymer materials, nanoparticles and Biomacromolecules to improve solubility, biocompatibility and drug release. In addition, BIS-PEG8-COOH can also be used in biomarkers and immunological research for modifying biomolecules such as proteins, peptides and antibodies.
Preparation method: The method of preparing BIS-PEG8-COOH usually involves a chemical reaction of the polymer. One common method of preparation is to obtain BIS-PEG8-COOH by reacting polyethylene glycol with cyclohexanedianhydride and then carboxylating the resulting esterified product.
Safety information: There is no detailed research data on the safety of BIS-PEG8-COOH. However, polyethylene glycol derivatives generally have good biocompatibility and low toxicity. During operation and use, follow appropriate laboratory safety practices, such as wearing protective gloves, glasses and laboratory clothing, and avoid inhalation, ingestion or contact with skin. If accidental exposure occurs, measures should be taken in a timely manner for cleaning and disposal. Observe local safety guidelines and regulatory requirements when using the BIS-PEG8-COOH.
Last Update：2024-04-09 20:52:54
Supplier List
Product Name: BIS-PEG8-COOH Visit Supplier Webpage Request for quotation
CAS: 1246189-43-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1246189-43-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: BIS-PEG8-COOH Visit Supplier Webpage Request for quotation
CAS: 1246189-43-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1246189-43-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History