125314-64-9
Ro 31-8220
CAS: 125314-64-9
Molecular Formula: C25H23N5O2S
125314-64-9 - Names and Identifiers
125314-64-9 - Physico-chemical Properties
| Molecular Formula | C25H23N5O2S |
| Molar Mass | 457.55 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | solid |
| Color | orange to red |
| pKa | 7.90±0.60(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | Ro 31-8220 is a potent PKC inhibitor, with IC 50 s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC 50 s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Moreover, Ro 31-8220 directly suppresses voltage-dependent Na + channels. Ro 31-8220 (1 μM) is neuroprotective against paraoxon-induced neuronal cell death in cerebellar granule neurons, blocks paraoxon-induced caspase-3 activity, and reduces the paraoxon-induced increase in phospho-PKC pan levels. |
| In vivo study | Ro 31-8220 (6 mg/kg/d, s.c.) is well tolerated, and has half-life of 5.7 hours in mice. Ro 31-8220-treated MLP −/− mice show a dramatic rescue in fractional shortening after treatment for 6 weeks, but the WT mice shows no change. |
125314-64-9 - Risk and Safety
| WGK Germany | 3 |
125314-64-9 - Introduction
Ro 31-8220 is a chemical substance with the chemical name Ro 31-8220, also known as Bisindolylmaleimide I. It is a broad-spectrum protein kinase inhibitor, mainly acting on protein kinase C (PKC) and other protein kinases.
The main use of Ro 31-8220 is in biomedical research, especially in cell signaling research. It can be used to study the function and regulation mechanism of PKC, and to verify its relevance to cellular processes (such as proliferation, differentiation, apoptosis, etc.). In addition, PD 31-8220 has also been used to study other protein kinases and related disease mechanisms.
Ro 31-8220 is generally prepared by chemical synthesis. Specific synthetic steps can be referred to the relevant literature and patents.
Safety precautions are required when using the Ro 31-8220. It is a potent protein kinase inhibitor with potential toxicity. Use should be carried out in strict accordance with laboratory practices, the necessary personal protective equipment (such as gloves, goggles, etc.) should also be equipped, and maintain good ventilation conditions. At the same time, Ro 31-8220 should also avoid reacting with other organic solvents and chemicals to avoid adverse effects.
The main use of Ro 31-8220 is in biomedical research, especially in cell signaling research. It can be used to study the function and regulation mechanism of PKC, and to verify its relevance to cellular processes (such as proliferation, differentiation, apoptosis, etc.). In addition, PD 31-8220 has also been used to study other protein kinases and related disease mechanisms.
Ro 31-8220 is generally prepared by chemical synthesis. Specific synthetic steps can be referred to the relevant literature and patents.
Safety precautions are required when using the Ro 31-8220. It is a potent protein kinase inhibitor with potential toxicity. Use should be carried out in strict accordance with laboratory practices, the necessary personal protective equipment (such as gloves, goggles, etc.) should also be equipped, and maintain good ventilation conditions. At the same time, Ro 31-8220 should also avoid reacting with other organic solvents and chemicals to avoid adverse effects.
Last Update：2024-04-09 21:11:58
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Product Name: Ro 31-8220 Visit Supplier Webpage Request for quotation
CAS: 125314-64-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 125314-64-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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