Name | DiAzKs |
Synonyms | DiAzKs H-L-Photo-lysine N6-[[2-(3-Methyl-3H-diazirin-3-yl)ethoxy]carbonyl]-L-lysine |
CAS | 1253643-88-7 |
Molecular Formula | C11H20N4O4 |
Molar Mass | 272.3 |
In vitro study | Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including 'readers' and 'erasers' of histone modifications. |
biological activity | H-L-Photo-lysine is a lysine amino acid containing a diazo group and is also a photocrosslinking agent. H-L-Photo-lysine can be selectively inserted into proteins and used to cross-link protein-protein interactions in vitro and in living cells. H-L-Photo-lysine is used as a UV-activated photocrosslinking probe. |