125697-93-0
LAVENDUSTIN C
CAS: 125697-93-0
Molecular Formula: C14H13NO5
125697-93-0 - Names and Identifiers
| Name | LAVENDUSTIN C |
| Synonyms | HDBA COMPOUND 5 LAVENDUSTIN C 5-(2,5-DIHYDROXYBENZYLAMINO)SALICYLIC ACID 5-(N-2,5-DIHYDROXYBENZYL)AMINOSALICYLIC ACID 5-(N-2',5'-DIHYDROXYBENZYL)AMINOSALICYLIC ACID 5-(2,5-DIHYDROXYBENZYLAMINO)-2-HYDROXYBENZOIC ACID 2-HYDROXY-5-(2,5-DIHYDROXYBENZYLAMINO)BENZOIC ACID [2-HYDROXY-5-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOIC ACID |
| CAS | 125697-93-0 |
125697-93-0 - Physico-chemical Properties
| Molecular Formula | C14H13NO5 |
| Molar Mass | 275.26 |
| Density | 1.551±0.06 g/cm3(Predicted) |
| Melting Point | 193-195°C dec. |
| Boling Point | 597.5±50.0 °C(Predicted) |
| Solubility | DMSO: soluble |
| Appearance | solid |
| Color | Light Beige to Brown |
| pKa | 2.32±0.10(Predicted) |
| Storage Condition | −20°C |
| Stability | Hygroscopic |
| In vitro study | Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase. Lavendustin C (10-150 µM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation. |
125697-93-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
125697-93-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.633 ml | 18.165 ml | 36.33 ml |
| 5 mM | 0.727 ml | 3.633 ml | 7.266 ml |
| 10 mM | 0.363 ml | 1.816 ml | 3.633 ml |
| 5 mM | 0.073 ml | 0.363 ml | 0.727 ml |
Last Update：2024-01-02 23:10:35
125697-93-0 - Reference Information
| biological activity | Lavendustin C is a potent inhibitor of Ca2 calmodulin-dependent kinase II (CaMK II), the IC50 was 0.2 μm. Lavendustin C inhibited EGFR-associated tyrosine kinase (IC50=0.012 µm) and pp60c-src() kinase (IC50=0.5 µm). |
Last Update：2024-04-09 19:05:17
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