1262410-84-3

1262410-84-3 - Names and Identifiers

Name	1-Boc-3-fluoropyrrolidine-3-Methanol
Synonyms	1-Boc-3-fluoropyrrolidine-3-Methanol 1-Boc-3-fluoro-3-hydroxymethylpyrrolidine tert-butyl 3-fluoro-3-(hydroxymethyl)pyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 3-fluoro-3-(hydroxymethyl)-, 1,1-dimethylethyl ester
CAS	1262410-84-3

1262410-84-3 - Physico-chemical Properties

Molecular Formula	C10H18FNO3
Molar Mass	219.2532232
Density	1.16±0.1 g/cm3(Predicted)
Boling Point	292.6±25.0 °C(Predicted)
pKa	14.93±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

1262410-84-3 - Introduction

It is an organic compound, commonly referred to as Boc-Fpom. The following is a description of the nature, use, preparation and safety information of the Boc-Fpom:

Nature:
-Appearance: Colorless to light yellow liquid or solid
-Molecular formula: C9H16FNO3
-Molecular weight: 201.23g/mol
-Density: approx. 1.2 g/ml
-Melting point: About 40-45 ℃ (solid form)
-Boiling point: About 200-210 ℃ (liquid form)
-Solubility: Soluble in common organic solvents, such as methanol, ethanol, etc.

Use:
- Boc-Fpom is an important organic synthesis intermediate, which has a wide range of applications in the field of drug synthesis.
-It is commonly used in the synthesis of fluorine-containing active drug molecules.
- Boc-Fpom may be used as a protecting group for the CH functional group, for example p-amino or hydroxy.
-It can also be used as a catalyst for esterification, amidation and other organic synthesis reactions.

Method:
The preparation method of Boc-Fpom is more complicated and may involve some organic synthesis techniques. A general method of preparation is as follows:
1. 3-fluoropyrrolidine-3-methanol is reacted with tert-butyl alcohol in a dry organic solvent to generate Boc-Fpom.
2. The reaction can be carried out at room temperature or under heating conditions, and generally requires the presence of a catalyst and a protective atmosphere (such as nitrogen).
3. After the reaction, the target product is obtained by distillation or extraction.

Safety Information:
-The Boc-Fpom is operated under normal laboratory conditions, referring to the general safe operation of organic compounds.
-It may be irritating to the eyes and skin, so personal protection, such as protective glasses, gloves and lab coats, should be used when exposed.
-When stored, it should be kept in a dry, cool place, away from fire and oxidizing agents.

Please note that the preparation and use of organic compounds requires some knowledge of laboratory techniques and safety. Before carrying out relevant operations, it is recommended to consult a professional and carefully read and comply with the safety data sheets (SDS) of relevant materials.

Last Update：2024-04-09 20:49:11