1262412-13-4

1262412-13-4 - Names and Identifiers

Name	1-Boc-3-amino-3-azetidinecarboxylic acid
Synonyms	1-Boc-3-aMino-3-azetidinecarboxylic acid 1-Boc-3-amino-3-azetidinecarboxylic acid 1-(tert-butoxycarbonyl)-3-aminoazetidine-3-carboxylic acid 3-amino-1-(tert-butoxycarbonyl)-3-azetidinecarboxylic acid 1,3-Azetidinedicarboxylic acid, 3-amino-, 1-(1,1-dimethylethyl) ester 3-amino-1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic acid
CAS	1262412-13-4

1262412-13-4 - Physico-chemical Properties

Molecular Formula	C9H16N2O4
Molar Mass	216.23
Density	1.291±0.06 g/cm3(Predicted)
Boling Point	350.2±42.0 °C(Predicted)
pKa	1.90±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

1262412-13-4 - Introduction

1-Boc-3-amino-3-azetidinic acid is a pharmaceutical intermediate with the following properties:

1. Appearance: colorless or white crystalline solid;
2. molecular formula: C14H20N2O4;
3. Molecular weight: 288.32g/mol;
4. melting point: 118-121 ℃;
5. solubility: soluble in most organic solvents, such as chloroform, methanol and dichloromethane.

1-Boc-3-amino-3-azetidinecarboxylic acid is mainly used in the synthesis of protecting groups and amino acids in organic synthesis.

Method:
1-Boc-3-amino-3-azetidinecarboxylic acid is generally synthesized by the following steps:
1.3-amino -3-azetidine carboxylic acid and Boc2O (tert-butoxycarbonyl chloride) are reacted in diethyl carbonate (Et2CO3) and dimethyl sulfoxide (DMSO) solvent to generate 1-Boc-3-amino-3-azetidine chloride;
2. 1-Boc-3-amino-3-azetidinoyl chloride was reacted with sodium hydride (NaH) in diethyl carbonate (Et2CO3) and methanol (MeOH) solvent to yield 1-Boc-3-amino-3-azetidinecarboxylic acid.

Safety Information:
1-Boc-3-amino-3-azetidinecarboxylic acid is a chemical and the following safety precautions should be taken:
1. avoid contact with skin and eyes, avoid inhalation of gas or solution;
2. use should wear personal protective equipment, such as gloves, goggles, etc;
3. storage should be sealed, away from the fire and oxidant.

Last Update：2024-04-10 22:29:15