1287241-26-2
PAC-1-d8
CAS: 1287241-26-2
Molecular Formula: C23H28N4O2
1287241-26-2 - Names and Identifiers
| Name | PAC-1-d8 |
| Synonyms | PAC-1-d8 [2H8]-PAC-1 YQNRVGJCPCNMKT-SRNXAORYSA-N |
| CAS | 1287241-26-2 |
1287241-26-2 - Physico-chemical Properties
| Molecular Formula | C23H28N4O2 |
| Molar Mass | 392.49402 |
| Storage Condition | 2-8°C |
1287241-26-2 - Reference Information
| Use | Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executive caspase and direct effector of apotosis. Hallmark of many caners is th e circuit of signal in the activation of executive caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0. 92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues. |
Last Update：2024-04-09 20:45:29
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CAS: 1287241-26-2
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CAS: 1287241-26-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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