129029-23-8

Name	Ocaperidone
Synonyms	R79598 Ocaperidona Ocaperidone Ocaperidone (R79598) 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2,9-dimethylpyrido[1,2-a]pyrimidin-4-one 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2,9-dimethyl-
CAS	129029-23-8

Molecular Formula	C24H25FN4O2
Molar Mass	420.48
Melting Point	180.0 to 184.0 °C
Appearance	powder to crystal
Color	White to Light yellow
Storage Condition	2-8°C
In vitro study	Ocaperidone has high affinify at 5-HT 2 and dopamine D 2 , with K i s of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5HT 2 , a 1 -adrenergic, dopamine D 2 , histamine H 1 and a 2 -adrenergic, respectively. Ocaperidone shows 5-HT 1A receptor agonist activity, with a pEC 50 and pK i of 7.60 and 8.08.
In vivo study	Ocaperidone shows a potent occupation of 5HT 2 receptor via in vivo binding in the frontal cortex of rats with an ED 50 of 0.04 mg/kg, and 0.1 4-0.1 6 mg/kg for D 2 receptor in the striatum and the nucleus accumbens. Ocaperidone (R 79598) antagonizes dopamine D 2 and 5-HT 2 , and shows a a partial generalization to buspirone with an ED 50 of 0.163 mg/kg.

Last Update：2024-01-02 23:10:35

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CAS: 129029-23-8
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129029-23-8

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