Name | Perospirone |
Synonyms | Lulla sm-9018 Perospirone PEROSPIRONE HYDROCHLORIDE Perospirone hydrochloride PEROSPIRONE HYDROCHLORIDE HYDRATE monohydrochloride,cis-yl)hexahydro PEROSPIRONE HYDROCHLORIDE DIHYDRATE 1h-isoindole-1,3(2h)-dione,2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)but (3aR,7aS)-rel-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione Hydrochloride Trihydrate |
CAS | 129273-38-7 |
InChI | InChI=1/C24H32N4O2S.ClH/c29-23-20-9-3-4-10-21(20)24(30)28(23)12-6-5-11-26-13-15-27(16-14-26)22-19-8-2-1-7-18(19)17-31-25-22;/h1-2,7-8,20-21H,3-6,9-17H2;1H/t20-,21+ |
Molecular Formula | C23H30N4O2S.HCl |
Molar Mass | 463.04 |
Melting Point | 95-970C |
Boling Point | 667.4℃ at 760 mmHg |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Appearance | White solid |
Color | White to Off-White |
Storage Condition | -20°C Freezer |
3 chlorine 1.2 a benzisothiazole and piperidine together at 120 deg C heating 20H. Dissolve in water and extract repeatedly with dichloromethane. The extracts were combined, dried and concentrated under reduced pressure. The resulting material was dissolved in diethyl ether, filtered and concentrated under reduced pressure to give 3-(1-piperazinyl) -1.2-benzisothiazole. The benzisothiazole and N-(4-bromobutyl) cyclohexanediimide were dissolved in acetonitrile, potassium carbonate and potassium iodide were added, and the reaction was refluxed to obtain the product.
developed by sumitmo Pharma, Japan, was first launched in Japan in 2001. Dopamine D2/5HT2 antagonist. For schizophrenia.