Name | Semilicoisoflavone B |
Synonyms | PSX005 SeMilicoisoflavone B Semilicoisoflavone B 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)- |
CAS | 129280-33-7 |
Molecular Formula | C20H16O6 |
Molar Mass | 352.34 |
Density | 1.443±0.06 g/cm3(Predicted) |
Boling Point | 615.5±55.0 °C(Predicted) |
Solubility | Very slightly soluble (0.11g/L) (25°C), |
Appearance | Oil |
pKa | 6.43±0.20(Predicted) |
Storage Condition | -20℃ |
Reference Show more | 1. [IF=4.36] Xiang-Yang Chen et al."Deciphering the effective combinatorial components from Si-Miao-Yong-An decoction regarding the intervention on myocardial hypertrophy."J Ethnopharmacol. 2021 May;271:113833 |
Plant Source: | licorice |
biological activity | Semilicoisoflavone B, an isoflavone, is mainly derived from glycyrhiza uralensis Fisch.. Semilicoisoflavone B reduces the secretion of amyloid β (Aβ) by inhibiting the expression and activity of β-secretase-1 (BACE1). Semilicoisoflavone B decreases BACE1 expression primarily by increasing PPARγ expression and inhibiting STAT3 phosphorylation. |