129499-78-1
Ascorbyl Glucoside
CAS: 129499-78-1
Molecular Formula: C12H18O11
129499-78-1 - Names and Identifiers
129499-78-1 - Physico-chemical Properties
| Molecular Formula | C12H18O11 |
| Molar Mass | 338.26 |
| Density | 1.83±0.1 g/cm3(Predicted) |
| Melting Point | 158-163℃ |
| Boling Point | 785.6±60.0 °C(Predicted) |
| Water Solubility | Soluble in water. (879 g/L) at 25°C. |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | White to white-like powder |
| Color | White to Off-white |
| Maximum wavelength(λmax) | ['260nm(H2O)(lit.)'] |
| pKa | 3.38±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD23701380 |
129499-78-1 - Risk and Safety
| WGK Germany | 3 |
129499-78-1 - Reference Information
| LogP | -2 at 20℃ |
| surface tension | 71mN/m at 1g/L and 20 ℃ |
| Introduction | ascorbic acid glucoside is also called VC glucoside, the scientific name O-a-D-glucopyranosyl-L-ascorbic acid (Δacid, abbreviated as AA-2G) is a derivative of VC with a relative molecular mass of 338.27 and a melting point of 158.5-159.5 °c. Due to the poor stability of VC, easy to be oxidized and other shortcomings, it is derived from the alternative product of VC ascorbic acid glucoside, which can replace VC as a acidulant, reducing agent, antioxidant, bleaching agent and stabilizer, widely used in cosmetics, food and medicine and other fields. |
| efficacy and action | 1. Lightening inhibits melanin formation after the conversion of ascorbyl glucoside into Vitamin C into skin cells, the effect of significantly reducing melanin formation is achieved by inhibiting the activity of tyrosinase. Inhibition of tyrosinase results in a decrease in dopaquinone, an intermediate in the synthesis of melanin. Another added benefit is the simultaneous conversion of DOPA quinone to levodopa, which relieves the already formed melanin and, in turn, reduces the pigmentation of the skin. 2. Resistance to UV damage inhibition of UV irradiation on cell damage after ascorbic acid glucoside into vitamin C, can greatly reduce the skin by ultraviolet irradiation of free radicals, significantly reduce skin damage, it plays a role in protecting the skin in sunscreen products. |
| Application | ascorbic acid glucoside is one of the whitening additives approved by the Department of Health, and is recognized as the most stable vitamin C derivative. At the same time, it is also the most commonly used whitening ingredients of major brands. For example, L-Oreal uses C- glycoside derivatives to act synergistically with other components for the prevention or treatment of signs of aging on the skin of the body or face. Ascorbic acid glucoside not only has good whitening effect, but also has stable chemical properties and no irritation to the skin. It is widely used in cosmetics at home and abroad, the following table lists the application of common vitamin C derivatives in cosmetics. |
| whitening principle | the content of the pigment in human skin determines the color of the skin, leucine is the main raw material for the production of the pigment, and tyrosinase is the rate-limiting enzyme in the tyrosine synthesis pathway, which affects the production of melanin mainly by affecting the conversion of tyrosine to DOPA and the oxidation of DOPA to dopaquinone. The whitening mechanism of ascorbyl glucoside is to inhibit the formation of melanin by inhibiting the activity of tyrosinase by using L-keto as a substrate. Its whitening principle can be confirmed by the following picture. |
| preparation | a method for producing ascorbyl glucoside, comprising the following steps: Step 1: The ascorbic acid glucoside reaction solution is separated by nanofiltration to remove the residual VC in the reaction solution to obtain nanofiltration concentrate; Step 2: the nanofiltration concentrate is separated by a continuous fluid separation device to remove glucose from the VC glucoside reaction solution; Step 3: the VC glucoside solution coming out from the continuous fluid separation device is first adjusted by a cation resin and then concentrated by a nanofiltration membrane to remove inorganic salts in the reaction solution to obtain a VC glucoside concentrated solution; Step 4: The concentrated VC glucoside solution is distilled and concentrated under reduced pressure to further increase the concentration of VC glucoside, and then crystallized to obtain VC glucoside. |
| biological activity |
Last Update：2024-04-09 20:45:29
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