13035-61-5

13035-61-5 - Names and Identifiers

Name	Beta-D-Ribofuranose 1,2,3,5-tetraacetate
Synonyms	TETRAACETYLRIBOSE TETRAACETYLRIBOFURANOSE 1,2,3,5-Tetra-O-acetyl- Tetraacetylribofuranose RIBOFURANOSE TETRAACETATE 1,2,3,5-Tetra-O-Acetyl-D-Ribose TETRA-O-ACETYL-B-D-RIBOFURANOSE TETRAACETYL-BETA-D-RIBOFURANOSE 1,2,3,5-tetraacetyl-beta-D-ribose TETRA-O-ACETYL-BETA-D-RIBOFURANOSE 1,2,3,5-tetra-O-acetylpentofuranose 1,2,3,5-Tetra-O-acetyl-D-ribofuranose 1,2,3,5-tetraacetyl-beta-D-ribofuranose 1,2,3,5-Tetra-O-acetyl-β-D-ribofuranose Beta-D-Ribofuranose 1,2,3,5-tetraacetate 1,2,3,5-tera-O-acetyl-beta-D-ribofuranose 1,2,3,5-tetra-O-acetyl-beta-D-ribofuranose [(2S,5R)-3,4-diacetoxy-5-(acetoxymethyl)tetrahydrofuran-2-yl] acetate
CAS	13035-61-5
EINECS	235-898-5
InChI	InChI=1/C13H18O9/c1-6(14)18-5-10-11(19-7(2)15)12(20-8(3)16)13(22-10)21-9(4)17/h10-13H,5H2,1-4H3/t10-,11?,12?,13-/m1/s1
InChIKey	TTXVPMATRDJQIA-BKUVIOGVSA-N

13035-61-5 - Physico-chemical Properties

Molecular Formula	C13H18O9
Molar Mass	318.28
Density	1.4171 (rough estimate)
Melting Point	81-83°C(lit.)
Boling Point	417.45°C (rough estimate)
Specific Rotation(α)	-15.4 º (c=7, MeOH)
Flash Point	168.5°C
Solubility	Chloroform (Sparingly), Methanol (Slightly)
Vapor Presure	3.76E-06mmHg at 25°C
Appearance	White crystalline powder
Color	White to almost white
BRN	94078
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	-14.5 ° (C=5, MeOH)
MDL	MFCD00005358
Physical and Chemical Properties	White or off-white crystals, odorless, with a slightly bitter taste. Soluble in ethyl acetate and chloroform, slightly soluble in water. Melting point 81.5-83 °c.
Use	As an intermediate of ribavirin

13035-61-5 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	29400090

13035-61-5 - Upstream Downstream Industry

Raw Materials

Inosine

13035-61-5 - Reference Information

introduction	tetraacetyl ribose (1,2,3,5-tetra-O-acetyl-D-ribofuranose), also known as 1,2,3,5-O-tetraacetyl-β-D-furanribose, the molecular formula is C13H18O9, which is generally prepared by degradation and acylation of nucleotides. its main industrial production method is to obtain products by acetylation, lysis and crystallization of nucleosides. In the above process, two isomers are mainly produced: 1,2,3, 5-tetra-O-acetyl-β-D-furanribose (β-tetraacetyl ribose for short) and 1,2,3, 5-Tetra-O-acetyl-α-D-furanribose (α-tetraacetyl ribose for short).
application	tetraacetyl ribose is an important intermediate for the production of antiviral drug triazole nucleoside in the pharmaceutical industry. it is mainly used for the synthesis of broad-spectrum antiviral drug ribavirin and is also the starting material for the synthesis of nucleoside compounds.
preparation	take a 1000mL flask, add 50g of inosine and 200ml of acetic anhydride, stir and heat to reflux, the internal liquid temperature is 120 ℃, clarify for about 60 minutes, cool to 100 ℃, add 10g of catalyst (NaSiO3 and Na2HPO4 are mixed according to 2: 1), keep the temperature at 110 ℃ for 2 hours, and connect to a Vickers fractionation column, the mixture of acetic acid and acetic anhydride was steamed under micro negative pressure, and 100ml of acid was steamed for about 100min. Continue to keep the temperature at 110 ℃ for 6 hours, and track the end point with a thin layer of color plate until triacetylinosine basically disappears. Cooling to 30 ℃, filtering, combining filtrate, vacuum evaporation of mixed acetic anhydride in a rotary evaporator, cooling the residue to 90-100 ℃, adding distilled water, 150ml, stirring, crystallization, precipitation of tetraacetyl ribose, the yield of the ribose is 94.8%.
use	intermediates such as ribavirin. the starting material for nucleoside (nucleoside) synthesis the starting material for nucleoside synthesis; D-ribose derivatives used for ribosylation; selective 1-0-deacetylation as an intermediate for triazole nucleoside

Last Update：2024-04-10 22:29:15

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View History

13035-61-5
TFAI

Raw Materials for 13035-61-5

Inosine

13035-61-5

Beta-D-Ribofuranose 1,2,3,5-tetraacetate

CAS: 13035-61-5

Molecular Formula: C13H18O9

13035-61-5 - Names and Identifiers

13035-61-5 - Physico-chemical Properties

13035-61-5 - Risk and Safety

13035-61-5 - Upstream Downstream Industry

13035-61-5 - Reference Information

Supplier List

13035-61-5 Request for Quotation

Beta-D-Ribofuranose 1,2,3,5-tetraacetate

CAS: 13035-61-5

Molecular Formula: C13H18O9

13035-61-5 - Names and Identifiers

13035-61-5 - Physico-chemical Properties

13035-61-5 - Risk and Safety

13035-61-5 - Upstream Downstream Industry

13035-61-5 - Reference Information

Supplier List

13035-61-5