1312782-34-5
AA26-9
CAS: 1312782-34-5
Molecular Formula: C7H10N4O
1312782-34-5 - Names and Identifiers
| Name | AA26-9 |
| Synonyms | AA26-9 Pyrrolidin-1-yl-[1,2,3]triazol-1-yl-methanone Methanone, 1-pyrrolidinyl-1H-1,2,3-triazol-1-yl- |
| CAS | 1312782-34-5 |
1312782-34-5 - Physico-chemical Properties
| Molecular Formula | C7H10N4O |
| Molar Mass | 166.18 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Boling Point | 306.7±25.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | -0.71±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells. |
1312782-34-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 6.018 ml | 30.088 ml | 60.176 ml |
| 5 mM | 1.204 ml | 6.018 ml | 12.035 ml |
| 10 mM | 0.602 ml | 3.009 ml | 6.018 ml |
| 5 mM | 0.12 ml | 0.602 ml | 1.204 ml |
Last Update：2024-01-02 23:10:35
1312782-34-5 - Reference Information
| biological activity | AA26-9 is a potent broad-spectrum serine hydrolase inhibitor. AA26-9 targets include serine peptidase, lipase, amidase, esterase and thioesterase. AA26-9 inhibited one third of the 40 serine hydrolases detected in the immortalized T cell line. |
| in vitro studies | AA26-9 is synthesized based on a pipe scaffold shown previously to inhibit amines in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from different functional subjects of serines, including lipases/phosphoripases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptides (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme's serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells. |
Last Update：2024-04-09 20:52:54
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Product Name: AA26-9 Visit Supplier Webpage Request for quotationCAS: 1312782-34-5
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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