132866-11-6

Name	Lercanidipine hydrochloride
Synonyms	LercanidipineHcl LERCANIDIPINE HCL Lercanidipine Impurity 1 LERCANIDIPINE HYDROCHLORIDE Lercanidipine hydrochloride 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimeth 3-(1-((3,3-Diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride
CAS	132866-11-6 100427-27-8
EINECS	603-682-3
InChI	InChI=1/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H
InChIKey	WMFYOYKPJLRMJI-UHFFFAOYSA-N

Molecular Formula	C36H42ClN3O6
Molar Mass	648.19
Melting Point	175-177°C
Boling Point	712.5°C at 760 mmHg
Flash Point	384.7°C
Solubility	soluble in Methanol
Vapor Presure	3.77E-20mmHg at 25°C
Appearance	powder
Color	yellow
Merck	14,5446
Storage Condition	2-8°C
MDL	MFCD07773089
Physical and Chemical Properties	Storage Conditions: 2-8 ℃
In vitro study	The calcium-antagonistic activity of Lercanidipine in vitro is associated with a gradual blockade of calcium influx into smooth muscle cells through L-type calcium channels. Lercanidipine inhibits the formation of cellular cholesteryl esters. At clinically used doses, Lercanidipine inhibits macrophage function in atherosclerosis formation as well as plaque stability in vitro.
In vivo study	In a canine model of Renovascular hypertension chronically catheterized, lercanidipine reduced diastolic blood pressure in a dose-dependent manner (ED25=0.9 mg/kg p.o.). Long-term treatment with lercanidipine will permanently lower diastolic blood pressure, indicating an intolerance to the hypotensive effect. Lercanidipine has a significant antispasmodic/anticonvulsant effect, in mice, it does not affect their muscle coordination and autonomic activity. In clinical studies, lercanidipine has a 24-hour antihypertensive effect without a significant increase in heart rate. In most patients with hypertension, lercanidipine is effective, the probability of adverse reactions is relatively low.

Hazard Symbols	T - Toxic
Risk Codes	25 - Toxic if swallowed
Safety Description	S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811
WGK Germany	3
Toxicity	LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi)

Last Update：2024-01-02 23:10:35

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CAS: 132866-11-6
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