132996-61-3
OSTEOGENIC GROWTH PEPTIDE
CAS: 132996-61-3
Molecular Formula: C68H110N22O18
132996-61-3 - Names and Identifiers
132996-61-3 - Physico-chemical Properties
| Molecular Formula | C68H110N22O18 |
| Molar Mass | 1523.74 |
| Storage Condition | −20°C |
| In vitro study | Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH 2 -ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells. |
132996-61-3 - Introduction
Amino acid sequence: Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly
Last Update：2022-10-16 17:41:12
132996-61-3 - Reference Information
| biological activity | Osteogenic Growth Peptide, OGP is a polypeptide composed of 14 amino acid residues, a promoting factor that has a systemic response to bone marrow damage and exists in mammalian serum at a concentration of μM. |
| in vitro study | Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C- terminus of histone H4, whose sequence contains a high conserved 14-amino acid motif (NH 2 -ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C- terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: OSTEOGENIC GROWTH PEPTIDE Visit Supplier Webpage Request for quotationCAS: 132996-61-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: OSTEOGENIC GROWTH PEPTIDE Visit Supplier Webpage Request for quotationCAS: 132996-61-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History