134419-59-3

134419-59-3 - Names and Identifiers

Name	Tetrahydro-2H-pyran-4-yl methanesulfonate
Synonyms	oxan-4-yl methanesulfonate Tetrahydropyran-4-yl methanesulfonate Tetrahydro-1H-pyran-4-yl methanesulfonate Tetrahydro-2H-pyran-4-yl methanesulfonate Tetrahydro-2H-pyran-4-ylmethanesulphonate Tetrahydro-2H-pyran-4-yl methanesulfonate 2H-Pyran-4-ol, tetrahydro-, methanesulfonate
CAS	134419-59-3

134419-59-3 - Physico-chemical Properties

Molecular Formula	C6H12O4S
Molar Mass	180.22
Density	1.26±0.1 g/cm3(Predicted)
Melting Point	47-49°C
Boling Point	329.1±31.0 °C(Predicted)
Solubility	Dichlromethane, DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Off-White to Pale Beige
Storage Condition	Inert atmosphere,Room Temperature
Stability	Moisture Sensitive

134419-59-3 - Reference Information

Application

4-tetrahydropyranyl methanesulfonate can be used as an intermediate in pharmaceutical synthesis, and can be prepared by the reaction of tetrahydropyran-4-ol and methanesulfonyl chloride. It can be used to prepare compound 1 ′-benzyl -6-((tetrahydro-2H-pyran-4-yl) oxy) spiroindene [-2,4 '-piperidine]-1(3H)-one.

preparation

4-tetrahydropyran mesylate is prepared as follows: MsCl(4.61g,40.24mmol) is added to DCM(100mL) solution of tetrahydropyran -4-alcohol (3.54g,34.66mmol) and triethylamine (4.65g,45.95mmol) at -10 ℃. After stirring for 30min, the reaction system was diluted with water (100mL) and extracted with DCM(100mL,50mL). The combined organic phase was washed with brine (1 × 50mL), dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 4-tetrahydropyranyl mesylate (6.74g).

Last Update：2024-04-10 22:29:15