134441-61-5

134441-61-5 - Names and Identifiers

Name	(R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
Synonyms	(R)-N-Boc-piperidine-2-methanol (R)-1-N-BOC-2-DROXYMETHYLPIPERIDINE (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE (2R)-1-Boc-2-(hydroxymethyl)piperidine (R)-N-(tert-Butoxycarbonyl)-2-piperidinemethanol (R)-tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate tert-Butyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate tert-Butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)-
CAS	134441-61-5
InChI	InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-7-5-4-6-9(12)8-13/h9,13H,4-8H2,1-3H3/t9-/m1/s1

134441-61-5 - Physico-chemical Properties

Molecular Formula	C11H21NO3
Molar Mass	215.29
Density	1.059
Boling Point	308.0±15.0 °C(Predicted)
Flash Point	140.1°C
Vapor Presure	6.41E-05mmHg at 25°C
pKa	15.08±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.479

134441-61-5 - Introduction

(R)-N-Boc-2-hydroxymethylpiperidine is an organic compound with the chemical formula (R)-[(tert-butoxycarbonyl)amino]methylpyridin-2-ol. It is a white to pale yellow solid.

Nature:
- (R)-N-Boc-2-hydroxymethylpiperidine is soluble in organic solvents such as ethanol and methylene chloride.
-It is a weak base, stable under neutral or acidic conditions.
-It can participate in nucleophilic reactions and metal-catalyzed reactions.

Use:
- (R)-N-Boc-2-hydroxymethylpiperidine is an important synthetic intermediate that can be used to synthesize a variety of organic compounds, such as drugs and pesticides.
-It can be used as a catalyst to participate in asymmetric synthesis reactions and produce compounds with optical activity.

Preparation Method:
(R)-N-Boc-2-hydroxymethylpiperidine can be synthesized by a two-step reaction.
In the first step, piperidine is reacted with methyl sodium bromide to obtain 2-hydroxymethylpiperidine.
In the second step, 2-hydroxymethylpiperidine is reacted with (Boc)2O to obtain (R)-N-Boc-2-hydroxymethylpiperidine.

Safety Information:
- (R)-N-Boc-2-Hydroxymethylpiperidine has limited safety information, so it is necessary to follow relevant laboratory safety procedures when using and handling.
-It may be harmful to the environment and should not be directly discharged into the natural environment.
-When storing, it should be stored in a dry, sealed container, away from heat and fire sources.

Last Update：2024-04-09 20:49:11