1351393-99-1
6-Methyl-1-(2-Methyl-6-trifluoroMethyl-benzyl)pyrimidine-2,4-dione
CAS: 1351393-99-1
Molecular Formula: C14H13F3N2O2
1351393-99-1 - Names and Identifiers
1351393-99-1 - Physico-chemical Properties
| Molecular Formula | C14H13F3N2O2 |
| Molar Mass | 298.26 |
1351393-99-1 - Introduction
1-(2-Fluoro-6-trifluoromethylbenzyl)-6-methyl -2,4(1H,3H)-dione, also known as FK866, is a chemical. Its nature, use, method and safety information are as follows:
Nature:
1-(2-Fluoro-6-trifluoromethylbenzyl)-6-methyl -2,4(1H,3H)-dione is a white or off-white solid. It is highly soluble and soluble in organic solvents such as dimethyl sulfoxide and methylene chloride.
Use:
1-(2-Fluoro-6-trifluoromethylbenzyl)-6-methyl -2,4(1H,3H)-dione is widely used as an anti-tumor drug. It is an inhibitor of NAD synthase (NAMPT), a key enzyme in the biosynthesis of nicotinic acid adenine dinucleotide (NAD). Therefore, FK866 can block the NAD biosynthesis pathway of cancer cells, thereby inhibiting the proliferation of cancer cells.
Preparation Method:
There are many methods for the synthesis of 1-(2-fluoro-6-trifluoromethylbenzyl)-6-methyl -2,4(1H,3H)-dione. One common method is by reacting the product of benzyl magnesium bromide and 2-fluoro-6-trifluoromethylbenzyl ketone, followed by a demethylation reaction to produce the desired product.
Safety Information:
The safety of FK866 is high, but it still needs to be used carefully. If there is a risk of ingestion, inhalation or skin contact, appropriate personal protective measures should be taken. In addition, FK866 should be stored in a cool, dry place, away from open flames and high temperatures. When using or handling FK866, the relevant safety procedures should be strictly observed. If contact or exposure occurs, seek medical attention or consult a professional immediately.
Nature:
1-(2-Fluoro-6-trifluoromethylbenzyl)-6-methyl -2,4(1H,3H)-dione is a white or off-white solid. It is highly soluble and soluble in organic solvents such as dimethyl sulfoxide and methylene chloride.
Use:
1-(2-Fluoro-6-trifluoromethylbenzyl)-6-methyl -2,4(1H,3H)-dione is widely used as an anti-tumor drug. It is an inhibitor of NAD synthase (NAMPT), a key enzyme in the biosynthesis of nicotinic acid adenine dinucleotide (NAD). Therefore, FK866 can block the NAD biosynthesis pathway of cancer cells, thereby inhibiting the proliferation of cancer cells.
Preparation Method:
There are many methods for the synthesis of 1-(2-fluoro-6-trifluoromethylbenzyl)-6-methyl -2,4(1H,3H)-dione. One common method is by reacting the product of benzyl magnesium bromide and 2-fluoro-6-trifluoromethylbenzyl ketone, followed by a demethylation reaction to produce the desired product.
Safety Information:
The safety of FK866 is high, but it still needs to be used carefully. If there is a risk of ingestion, inhalation or skin contact, appropriate personal protective measures should be taken. In addition, FK866 should be stored in a cool, dry place, away from open flames and high temperatures. When using or handling FK866, the relevant safety procedures should be strictly observed. If contact or exposure occurs, seek medical attention or consult a professional immediately.
Last Update：2024-04-09 20:52:54
