135716-08-4

135716-08-4 - Names and Identifiers

Name	tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
Synonyms	Ethyl 2-(1-Boc-4-piperidylidene)acetate 1-piperidinecarboxylic acid, 4-(2-ethoxy-2-oxoethylidene)- 4-(Ethoxycarbonylmethylene)-1-(tert-butoxycarbonyl)piperidine tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidin-1-carboxylate tert-Butyl 4-(2-ethoxy-2-oxoethylidene)-1-piperidinecarboxylate tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 2-Methyl-2-propanyl 4-(2-ethoxy-2-oxoethylidene)-1-piperidinecarboxylate 4-[(Ethoxycarbonyl)methylene]piperidine-1-carboxylic acid tert-butyl ester 1-Piperidinecarboxylic acid, 4-(2-ethoxy-2-oxoethylidene)-, 1,1-diMethylethyl ester
CAS	135716-08-4
InChI	InChI=1S/C14H23NO4/c1-5-18-12(16)10-11-6-8-15(9-7-11)13(17)19-14(2,3)4/h10H,5-9H2,1-4H3

135716-08-4 - Physico-chemical Properties

Molecular Formula	C14H23NO4
Molar Mass	269.34
Density	1.129
Melting Point	85 °C
Boling Point	354℃
Flash Point	168℃
pKa	-1.46±0.20(Predicted)
Storage Condition	2-8°C
Sensitive	Irritant
MDL	MFCD12912655
Use	This product is for scientific research only and shall not be used for other purposes.

135716-08-4 - Risk and Safety

Hazard Class

IRRITANT

135716-08-4 - Introduction

tert-Butyl 4-(2-ethoxy-2-oxoethylidene) piperidine-l-carboxylate tert-butyl ester, chemical formula C15H27NO4, is also known as piperidine ester tert-butyrate. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless or light yellow liquid.
-Density: about 0.97g/cm³.
-Boiling point: about 290 ℃.
-Melting point: about -68 ℃.
-Solubility: Soluble in organic solvents, such as ethanol, ether, etc.

Use:
-tert-Butyl 4-(2-ethoxy-2-oxoethylidene) piperidine-1-carboxylic acid tert-butyl ester is mainly used as a pharmaceutical intermediate and can be used in the synthesis of certain drugs.

Preparation Method:
The synthesis of tert-butyl 4-(2-ethoxy-2-oxoethylidene) piperidine -1-carboxylic acid tert-butyl ester can be completed by the following steps: first, tert-butyl aerobic piperidine formate The salt reacts with ethyl fluoroalcohol to generate the corresponding ethyl fluoroether compound; then, the obtained ethyl fluoroether is transesterified with tert-butyl formate; finally, the obtained product is subjected to esterification reaction by acid catalysis to obtain the target product.

Safety Information:
-The compound may cause irritation and corrosion to the human body, so appropriate personal protective measures should be taken, such as wearing gloves and protective clothing.
-Avoid contact with skin and eyes, use safety glasses and protective mask if necessary.
-Avoid contact with oxidants, acids and alkalis during use and storage.
-If the substance is inhaled or ingested, seek medical attention immediately and show your safety data sheet to your doctor.

Last Update：2024-04-09 21:01:54