135897-06-2

biological activity	SB-218078 is a potent, selective, an ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. The inhibitory effect of SB-218078 on Cdc2 (IC50 250 nM) and PKC (IC50 1000 nM) was weak. SB-218078 induction of apoptosis by DNA damage and cell cycle arrest.
Cell Line:	HeLa cells HeLa and HT-29 cells
Concentration:	2.5 μM, 5 μM 500 nM, 625 nM
Incubation Time:	18 hours 96 hours
Result:	Abrogated G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Enhanced cytotoxicity of DNA damage. Promoted a strong increase of γ-H2AX and apoptosis throughout the lymphoma.
Animal Model:	C57/Bl6 mice injected with ARF -/- lymphomas
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; for 16 hours

Last Update：2024-04-10 22:29:15

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CAS: 135897-06-2
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Email: 3008007409@qq.com
Mobile: 18021002903
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135897-06-2

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