136194-77-9
Go6976
CAS: 136194-77-9
Molecular Formula: C24H18N4O
136194-77-9 - Names and Identifiers
136194-77-9 - Physico-chemical Properties
| Molecular Formula | C24H18N4O |
| Molar Mass | 378.43 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Melting Point | >221°C (dec.) |
| Boling Point | 652.3±55.0 °C(Predicted) |
| Solubility | Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly, |
| Appearance | Off-white solid |
| Color | White to Off-White |
| pKa | 14.39±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | Go6976 had no effect on the kinase activity of the Ca(2 +)-Independent PKC subtypes δ,ε, and ζ. In addition to WT JAK2,Go6976 also inhibits mutant hematological malignancies (JAK2 V617F and TEL-JAK2) and has activity against mutant FLT3. In AML cells, Go6976 reduced the viability in FLT3-ITD of the samples to 55% of the control and 69% in FLT3-WT. Go 6976 effectively inhibited Bryostatin 1, tumor necrosis factor alpha and interleukin 6 induced by HIV-1. |
| In vivo study | Go 6976 (2.5 mg/kg I. p.), as a PKD inhibitor, it effectively prevents acute liver injury induced by LPS/D:-GalN by inhibiting the activation of MAPKs to reduce the production of TNF-α, and significantly improve the survival rate of mice LPS/D-GalN Aggression. |
136194-77-9 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
136194-77-9 - Introduction
Go6976 is a biologically active small molecule compound that belongs to a class of protein kinase C (PKC) inhibitors. Its chemical name is 12-(2-Cyanoethyl)-6,7,12, [2,3-a]pyrrolo[3,4-c]carbazole-12-carboxylic acid ester.
Go6976 is commonly used to study the function and signaling pathways of PKC. PKC is an important class of cell signaling enzymes that play a critical role in cell growth, differentiation and survival. Go6976 can selectively inhibit the activity of PKC, thereby interfering with PKC-mediated cellular functions and the aging process.
The method of preparing Go6976 is relatively complex and generally involves a multi-step organic synthesis process. It can be synthesized by a variety of synthetic routes, such as the method of Criswell et al., the method of Porath et al. and the method of Zhu Shaopeng et al.
When using Go6976, you need to pay attention to some safety information. Go6976 is a toxic compound that is irritating and mutagenic. Strictly follow the safe handling of chemicals and use appropriate personal protective equipment, such as gloves, goggles and laboratory clothing. In addition, Go6976 should be stored dry, sealed and protected from light, avoiding contact with oxygen, strong oxidants and light. Avoid inhalation, swallowing or skin contact should immediately rinse with plenty of water. Most importantly, Go6976 should only be used in a suitable laboratory environment and in compliance with local laws and regulations.
Go6976 is commonly used to study the function and signaling pathways of PKC. PKC is an important class of cell signaling enzymes that play a critical role in cell growth, differentiation and survival. Go6976 can selectively inhibit the activity of PKC, thereby interfering with PKC-mediated cellular functions and the aging process.
The method of preparing Go6976 is relatively complex and generally involves a multi-step organic synthesis process. It can be synthesized by a variety of synthetic routes, such as the method of Criswell et al., the method of Porath et al. and the method of Zhu Shaopeng et al.
When using Go6976, you need to pay attention to some safety information. Go6976 is a toxic compound that is irritating and mutagenic. Strictly follow the safe handling of chemicals and use appropriate personal protective equipment, such as gloves, goggles and laboratory clothing. In addition, Go6976 should be stored dry, sealed and protected from light, avoiding contact with oxygen, strong oxidants and light. Avoid inhalation, swallowing or skin contact should immediately rinse with plenty of water. Most importantly, Go6976 should only be used in a suitable laboratory environment and in compliance with local laws and regulations.
Last Update：2024-04-09 20:52:54
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Mobile: +86-18821248368
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Product Name: Go6976 Visit Supplier Webpage Request for quotationCAS: 136194-77-9
Tel: +86-400-900-4166
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Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Product Name: Go6976 Visit Supplier Webpage Request for quotation
CAS: 136194-77-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 136194-77-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
136194-77-9
(-)-5-(benzoyloxy)hexahydro-2-oxo-2H-cyclo-penta
Mal-PEG6-acid
450-93-1
164165-77-9
33036-62-3
98273-59-7
188582-62-9
41463-77-8
1154178-68-3
(-)-5-(benzoyloxy)hexahydro-2-oxo-2H-cyclo-penta
Mal-PEG6-acid
450-93-1
164165-77-9
33036-62-3
98273-59-7
188582-62-9
41463-77-8
1154178-68-3