1365531-93-6

1365531-93-6 - Names and Identifiers

Name	(R)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl
Synonyms	(R)-2,2'-Bis[bis(4-methoxy-3,5-dimethyL (R)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl (R)-2,2'-Bis[bis(4-Methoxy-3,5-diMethylphenyl)phosphino]-4,4',6,6'-tetraMethoxybiphenyl (R)-DMM-Garphos Phosphine, 1,1'-[(1R)-4,4',6,6'-tetramethoxy[1,1'-biphenyl]-2,2'-diyl]bis[1,1-bis(4-methoxy-3,5-dimethylphenyl)-
CAS	1365531-93-6

1365531-93-6 - Physico-chemical Properties

Molecular Formula	C52H60O8P2
Molar Mass	874.98
Appearance	crystal
Color	white
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Sensitive	Air Sensitive

1365531-93-6 - Introduction

(R)-2,2 '-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6 '-tetramethoxy)-1,1'-biphenyl is an organic compound commonly known by the abbreviation (R)-BINAP. The following is a description of its nature, use, preparation and safety information:

Nature:
(R)-BINAP is a colorless crystal or white powder with a chemical formula of C44H44O8P2 and a molar mass of 758.77g/mol. It is a chiral compound and exhibits optical rotation. Its melting point is about 143-145°C.

Use:
(R)-BINAP is an important chiral ligand, which is widely used in catalytic organic synthesis. It can form stable chiral catalysts with transition metal complexes for asymmetric catalytic reactions in asymmetric synthesis. Due to its high enantioselectivity and catalytic activity, it is widely used in the synthesis of pharmaceutical raw materials, the synthesis of natural products and the construction of heterocyclic compounds.

Preparation Method:
The preparation of (R)-BINAP usually requires a multi-step reaction. One commonly used method is synthesis by enantioselective thiolation reactions. The specific method is as follows: First, 4-methoxy-3, 5-dimethylbromobenzene is reacted with excess dimethyl sulfoxide to produce 4-methoxy-3, 5-dimethylphenyl sulfoxide. Subsequently, the sulfoxide is reacted with dibromobiphenyl to form (R)-BINAP by titration with sodium solution.

Safety Information:
(R)-BINAP is not particularly hazardous under normal process conditions. However, when handling chemicals, follow general laboratory safety practices and wear appropriate personal protective equipment. Avoid contact with skin and eyes, and avoid inhaling its dust. If accidentally inhaled or in contact with the skin and eyes should be promptly rinsed. Please store and handle the compound properly, and pay attention to the ventilation conditions of the storage environment.

Last Update：2024-04-09 21:01:54