1365531-94-7

1365531-94-7 - Names and Identifiers

Name	(S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl
Synonyms	(S)-2,2'-Bis[bis(4-Methoxy-3,5-diMethylphenyl)phosphino]-4,4',6,6'-tetraMethoxybiphenyl (S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl (S)-2,2'-Bis[bis(4-Methoxy-3,5-diMethylphenyl)phosphino]-4,4',6,6'-tetraMethoxybiphenyl (S)-DMM-Garphos Phosphine, 1,1'-[(1S)-4,4',6,6'-tetramethoxy[1,1'-biphenyl]-2,2'-diyl]bis[1,1-bis(4-methoxy-3,5-dimethylphenyl)-
CAS	1365531-94-7

1365531-94-7 - Physico-chemical Properties

Molecular Formula	C52H60O8P2
Molar Mass	874.98
Boling Point	865.4±65.0 °C(Predicted)
Appearance	crystal
Color	white
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Sensitive	Air Sensitive

1365531-94-7 - Introduction

(S)-2,2 '-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6 '-tetramethoxy)-1,1'-biphenyl, also known as (S)-BINAP, is an organophosphorus ligand. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance:(S)-BINAP is a white to pale yellow crystal.
-Solubility: It is soluble in most organic solvents, such as dimethylformamide, acetonitrile, dichloromethane, etc.

Use:
(S)-BINAP is widely used as a ligand in metal catalysis and asymmetric synthesis:
-Metal catalysis: It can form complexes with transition metals and play an important role in a variety of catalytic reactions, such as asymmetric hydrogenation, asymmetric ethylene glycol synthesis, asymmetric carbonylation and so on.
-Asymmetric synthesis: As a chiral ligand,(S)-BINAP can be used to synthesize chiral organic compounds, such as chiral drugs and fine chemicals.

Preparation Method:
(S)-BINAP can be synthesized by the following steps:
1. First, the phosphorylation reaction is carried out on the basis of 4-methoxy -3,5-dimethylphenol to introduce the phosphate group into the benzene ring.
2. Subsequently, a substitution reaction was performed to substitute the two phosphate groups with 4-methoxy-3, 5-dimethylphenyl groups.
3. Finally, the two benzene rings were connected by aromatic carbonylation to obtain the target product (S)-BINAP.

Safety Information:
There is limited safety data on (S)-BINAP, but in general, it is considered a relatively safe compound. However, like other organophosphorus compounds, it may be toxic and irritating to the human body. When handling and handling (S)-BINAP, follow the necessary laboratory safety procedures and wear personal protective equipment.

Last Update：2024-04-09 21:01:54