13674-87-8
Tris(1,3-Dichloro-2-Propyl)Phosphate
CAS: 13674-87-8
Molecular Formula: C9H15Cl6O4P
13674-87-8 - Names and Identifiers
| Name | Tris(1,3-Dichloro-2-Propyl)Phosphate |
| Synonyms | TDCP Fyrol Fr 2 Tris-(2-chloroisopropyl) phosphate Tris(1,3-dichloroisopropyl)phosphate Tris(1,3-Dichloro-2-Propyl)Phosphate Tris (1,3-dichloro-2-propyl)phosphate tris(1,3-dichloropropan-2-yl) phosphate Phosphoric acid tris(1,3-dichloro-2-propyl) ester |
| CAS | 13674-87-8 |
| EINECS | 237-159-2 |
| InChI | InChI=1/C9H15Cl6O4P/c10-1-7(2-11)17-20(16,18-8(3-12)4-13)19-9(5-14)6-15/h7-9H,1-6H2 |
| InChIKey | ASLWPAWFJZFCKF-UHFFFAOYSA-N |
13674-87-8 - Physico-chemical Properties
| Molecular Formula | C9H15Cl6O4P |
| Molar Mass | 430.90 |
| Density | 1.487g/cm3 |
| Melting Point | -64℃ |
| Boling Point | 457.4°C at 760 mmHg |
| Flash Point | 377.7°C |
| Water Solubility | <0.1 g/100 mL at 24℃ |
| Vapor Presure | 4.07E-08mmHg at 25°C |
| Appearance | solid |
| Storage Condition | Room Temprature |
| Stability | Stable. Reacts slowly with aqueous acids and alkalies. May soften plastics. |
| Refractive Index | 1.497 |
| MDL | MFCD00083121 |
| Physical and Chemical Properties | TDCPP is a chlorinated analog of tris (2, 3-dibromopropyl) phosphate (Tris), which is one of the most detected organophosphorus flame retardants (OPFR) in the environment. |
| Use | Used in mining belt, cable, electrical, wallpaper, leather and other industries |
13674-87-8 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R38 - Irritating to the skin R20 - Harmful by inhalation R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 3082 9/PG 3 |
| WGK Germany | 2 |
| RTECS | UB1473000 |
| HS Code | 29199000 |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 1.85 g/kg (Piotrowski) |
13674-87-8 - Reference
| Reference Show more | 1. Guo, Ming, Yi Gu, and Xiaoyue Fan. "Chlorinated phosphorus flame retardants exert oxidative damage to SMMC-7721 human hepatocarcinoma cells." Science of The Total Environment 705 (2020): 135777.https://doi.org/10.1016/j.scitotenv.2019.135777 2. [IF=7.963] Ming Guo et al."Chlorinated phosphorus flame retardants exert oxidative damage to SMMC-7721 human hepatocarcinoma cells."Sci Total Environ. 2020 Feb;705:135777 |
13674-87-8 - In vitro study
At concentrations> 68 μg/mL, exposure to TDCPP did not significantly affect cell viability. After exposure to 136 μg/mL TDCPP, HCEC showed a 16% loss of cell viability. In addition, TDCPP was exposed to ≥ 272 μg/mL TDCPP. Based on cell viability, using nonlinear regression, the LC 50 value of TDCPP was 202 μg/mL. TDCPP-exposed cell apoptosis showed a concentration-dependent increase compared to controls. Compared with the control group, anti-apoptotic Bcl-2 protein expression increased to 1.4-fold after exposure to 2 μg/mL TDCPP, increased to 1.2-fold at 20 μg/mL, but decreased dynamically to 0.4-fold at 200 μg/mL. Under the condition of 200 μg/mL TDCPP, the activity of cysteine aspartate -3 increased to 2.1 times that of the control. TDCPP inhibited cell growth at lower concentrations (27 μM for IC 50), while cell viability and toxicity were affected at higher concentrations (171 μM and 168 μM for IC 50, respectively).
Last Update：2024-04-10 22:43:14
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