13675-18-8
TETRAHYDROXYDIBORON
CAS: 13675-18-8
Molecular Formula: B2H4O4
13675-18-8 - Names and Identifiers
| Name | TETRAHYDROXYDIBORON |
| Synonyms | sub-Boric acid Hypoboric acid Hypodiboric acid TETRAHYDROXYDIBORON Tetrahydroxydiborane tetrahydroxydiborane (Dihydroxyboranyl)boronic acid Tetrahydroxydiborane, Diboronic acid |
| CAS | 13675-18-8 |
| InChI | InChI=1/B2H4O4/c3-1(4)2(5)6/h3-6H |
13675-18-8 - Physico-chemical Properties
| Molecular Formula | B2H4O4 |
| Molar Mass | 89.65 |
| Density | 1.435±0.06 g/cm3(Predicted) |
| Melting Point | >385 °C |
| Solubility | soluble in Methanol |
| Appearance | White to yellow to brown powder |
| Color | white |
| pKa | 8.62±0.43(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | moisture sensitive |
| Refractive Index | 1.397 |
| MDL | MFCD05663888 |
13675-18-8 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/22 - Harmful by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
13675-18-8 - Reference Information
| Application | Tetrahydroxydiboron is mainly used to synthesize pharmaceutical intermediates in Suzuki coupling. The earliest synthesis of tetrahydroxydiboron can be traced back to 1955 years. Wartik uses zinc electrode inserted into liquid boron trichloride to generate diboron tetrachloride, then diboron tetrachloride reacts with water to first generate tetrahydroxydiboron, and then heats to 220 ℃ for dehydration to generate (BO)X; In 1961, the McCloskey was adopted at 0 ℃, quantitative hydrochloric acid was added dropwise to tetrakis (dimethylaminogroup) biobon and water mixture to generate tetrahydroxydiboron with 56% yield. In the next five decades, there was almost no public method report in the literature, until Molander 2012 once again mentioned the use of the latter method to synthesize tetrahydroxydiboron. |
| preparation | after adding 10% hydrochloric acid (4.5eq) in the reaction bottle, the temperature is reduced to 0 ℃, tetra (dimethylaminogroup) boborb (39.6g,0.2mol,1.0eq) is slowly added into the above hydrochloric acid solution dropwise. during the dropwise process, solids gradually precipitate out, and the dropwise addition is completed, gradually raised to room temperature, kept warm, stirred for 3 hours, filtered to obtain a white solid product of 16.9g after vacuum drying at 40-60 ℃, with a yield of 94.2%;GC derivatization (dissolving the product in methanol, adding pinanol derivatization) detection content 97.9%,HPLC:99.5%;HNMR(DMSO-d6 H2O):8.84(0.02),8.61(1.00), 7.59(5.28),6.50(0.02){Note: Peak area value in brackets}; The above products are added with 60mL of 0.05% dilute hydrochloric acid, the temperature is controlled at 5-10 ℃, stirred for 30 minutes, filtered, and the obtained solid is dried at 40-60 ℃ to obtain 16.5g of white product. |
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: TETRAHYDROXYDIBORON Request for quotationCAS: 13675-18-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: TETRAHYDROXYDIBORON Request for quotationCAS: 13675-18-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: TETRAHYDROXYDIBORON Request for quotation
CAS: 13675-18-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 13675-18-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Tetrahydroxydiboron Visit Supplier Webpage Request for quotationCAS: 13675-18-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: TETRAHYDROXYDIBORON Request for quotation
CAS: 13675-18-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 13675-18-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
Spot supply
Product Name: TETRAHYDROXYDIBORON Request for quotationCAS: 13675-18-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: TETRAHYDROXYDIBORON Request for quotationCAS: 13675-18-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: TETRAHYDROXYDIBORON Request for quotation
CAS: 13675-18-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 13675-18-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Tetrahydroxydiboron Visit Supplier Webpage Request for quotationCAS: 13675-18-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: TETRAHYDROXYDIBORON Request for quotation
CAS: 13675-18-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 13675-18-8
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
View History