136831-48-6
RG13022
CAS: 136831-48-6
Molecular Formula: C16H14N2O2
136831-48-6 - Names and Identifiers
| Name | RG13022 |
| Synonyms | RG13022 RG-13022 TYRPHOSTIN RG 13022 α-(3-Pyridyl)-3,4-dimethoxybenzeneacrylonitrile ALPHA-(3'-PYRIDYL)-(3,4-DIMETHOXY)CINNAMONITRILE 3-(3,4-dimethoxyphenyl)-2-(pyridin-3-yl)acrylonitrile 3-(3,4-Dimethoxyphenyl)-2-(3-pyridinyl)propenenitrile 2-(3,4'-DIMETHOXYPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE 3-Pyridineacetonitrile,a-[(3,4-dimethoxyphenyl)methylene]- |
| CAS | 136831-48-6 |
136831-48-6 - Physico-chemical Properties
| Molecular Formula | C16H14N2O2 |
| Molar Mass | 266.29 |
| Melting Point | 116.0 to 120.0 °C |
| Solubility | DMSO: 10 mM |
| Appearance | White solid. |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| In vitro study | RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC 50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC 50 s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively. RG-13022 inhibits not only EGF-induced growth but also growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. RG-13022 also totally blocks estrogen-stimulated phosphorylation of the EGF receptor, as well as estrogen-induced cell proliferation, suggesting that functioning TK pathways are required for estrogen action. |
| In vivo study | RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice. |
136831-48-6 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
136831-48-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.755 ml | 18.776 ml | 37.552 ml |
| 5 mM | 0.751 ml | 3.755 ml | 7.51 ml |
| 10 mM | 0.376 ml | 1.878 ml | 3.755 ml |
| 5 mM | 0.075 ml | 0.376 ml | 0.751 ml |
Last Update：2024-01-02 23:10:35
136831-48-6 - Introduction
RG13022 is a compound whose chemical name is N-(4-(2-(3-bromophenyl) ethoxy) phenyl)-3-methylpropionamide. The following is a description of the nature, use, preparation and safety information of RG13022:
Nature:
RG13022 is a white crystalline solid with high thermal stability and solubility. Its chemical structure contains a benzene ring and a methylpropionamide functional group.
Use:
RG13022 is a compound with potential pharmaceutical activity. According to research, it may have anti-tumor, anti-inflammatory and antioxidant activities. In addition, RG13022 has been used in the synthesis of other organic compounds and as a reagent in chemical research.
Preparation Method:
The preparation method of RG13022 is more complicated, and it is generally synthesized by organic synthesis route. The key step is to synthesize the intermediate of RG13022 and convert it to the final product by further reaction.
Safety Information:
The safety data on RG13022 is limited, so use needs to follow appropriate laboratory practices and safety measures. During the operation, pay attention to avoid contact with the skin and inhalation of its vapor. At the same time, it should be stored in a dry, well-ventilated place, away from fire and oxidizing agents. In case of contact or misuse, medical treatment should be provided in time and the corresponding chemical information should be provided. It is best to use and handle RG13022 in a qualified chemical laboratory.
Nature:
RG13022 is a white crystalline solid with high thermal stability and solubility. Its chemical structure contains a benzene ring and a methylpropionamide functional group.
Use:
RG13022 is a compound with potential pharmaceutical activity. According to research, it may have anti-tumor, anti-inflammatory and antioxidant activities. In addition, RG13022 has been used in the synthesis of other organic compounds and as a reagent in chemical research.
Preparation Method:
The preparation method of RG13022 is more complicated, and it is generally synthesized by organic synthesis route. The key step is to synthesize the intermediate of RG13022 and convert it to the final product by further reaction.
Safety Information:
The safety data on RG13022 is limited, so use needs to follow appropriate laboratory practices and safety measures. During the operation, pay attention to avoid contact with the skin and inhalation of its vapor. At the same time, it should be stored in a dry, well-ventilated place, away from fire and oxidizing agents. In case of contact or misuse, medical treatment should be provided in time and the corresponding chemical information should be provided. It is best to use and handle RG13022 in a qualified chemical laboratory.
Last Update：2024-04-09 21:31:55
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Product Name: RG13022 Visit Supplier Webpage Request for quotationCAS: 136831-48-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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