13720-94-0

13720-94-0 - Names and Identifiers

Name	4-Chloroquinoline-3-carboxylic acid ethyl ester
Synonyms	NSC 136916 NSC 109461 AURORA 18125 4-CHLORO-3-QUINOLINECARBOXYLATE ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE ETHYL 4-CHLOROQUINOLINE-3-CARBOXYLATE ethyl 4-chloroquinoline-3-carboxylate 4-Chloroquinoline-3-carboxylic acid ethyl ester 4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester
CAS	13720-94-0
InChI	InChI=1/C12H10ClNO2/c1-2-16-12(15)9-7-14-10-6-4-3-5-8(10)11(9)13/h3-7H,2H2,1H3
InChIKey	DWXQUAHMZWZXHP-UHFFFAOYSA-N

13720-94-0 - Physico-chemical Properties

Molecular Formula	C12H10ClNO2
Molar Mass	235.67
Density	1.286
Melting Point	46-48°C
Boling Point	128-129 °C(Press: 0.2 Torr)
Flash Point	152.5°C
Vapor Presure	0.000189mmHg at 25°C
Appearance	powder to crystal
Color	White to Orange to Green
pKa	1.78±0.24(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.609
MDL	MFCD00173407

13720-94-0 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
Hazard Class	IRRITANT

13720-94-0 - Introduction

4-Chloroquinoline-3-methylethyl ester, also known as 4-Chloroquinoline-3-methyl acetate, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 4-Chloroquinoline -3-methyl ethyl ester is a colorless to pale yellow oily liquid.
-Melting point: Its melting point range is -80°C to -60°C.
-Boiling point: Its boiling point is about 180°C to 190°C.
-Solubility: Soluble in organic solvents such as chloroform and ethanol, almost insoluble in water.

Use:
-4-chloroquinoline -3-methyl ethyl ester is often used as an intermediate in organic synthesis. It can be further reacted for the synthesis of other compounds.
-It is also an important intermediate in the pharmaceutical field, used to synthesize the antimalarial drugs quinoline and o-chloroquine.

Preparation Method:
-4-chloroquinoline -3-methyl ethyl ester can be prepared by a variety of methods. A common preparation method is to react 3-methylquinoline with chloroacetic acid or ethyl chloroacetate, introduce chlorine atoms through substitution reaction, and esterify the methyl group and acetyl group on the quinoline ring.

Safety Information:
-4-chloroquinoline -3-methyl ethyl ester need to pay attention to safety when using. It may be irritating to the eyes, skin and respiratory system. Avoid contact with skin, eyes and use. At the same time, operate in a well-ventilated area and be equipped with appropriate protective equipment, such as gloves, goggles and protective masks.
-When storing, it should be stored in a cool, dry place, away from fire and flammable materials.
-When disposing of waste, follow local regulations and properly dispose of remaining 4-chloroquinoline-3-methylethyl ester.

Last Update：2024-04-09 21:11:58