137504-86-0

137504-86-0 - Names and Identifiers

Name	4-Chloro-3-fluorobenzeneboronic acid
Synonyms	AKOS BRN-0033 BIO-FARMA BF000449 4-Chloro-3-fluoroben 3-fluoro-4-Chlorophenylboronic acid 4-CHLORO-3-FLUOROPHENYLBORONIC ACID 4-Chloro-3-fluorobenzeneboronic acid dihydroxy(3-fluoro-4-chlorophenyl)-borane 4-Chloro-3-fluorophenylboronic Acid (contains varying aMounts of Anhydride) 4-Chloro-3-fluorobenzeneboronic acid (contains varying aMounts of anhydride)
CAS	137504-86-0
InChI	InChI=1/C6H5BClFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,10-11H

137504-86-0 - Physico-chemical Properties

Molecular Formula	C6H5BClFO2
Molar Mass	174.37
Density	1.41±0.1 g/cm3(Predicted)
Melting Point	198-204℃
Boling Point	302.6±52.0 °C(Predicted)
Flash Point	136.8°C
Vapor Presure	0.000434mmHg at 25°C
Appearance	Solid
pKa	7.31±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.533
MDL	MFCD01319010

137504-86-0 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. S60 - This material and its container must be disposed of as hazardous waste. S37 - Wear suitable gloves.
HS Code	29319000
Hazard Class	IRRITANT

137504-86-0 - Introduction

4-Chloro-3-fluorophenylboronic acid is an organic boron compound with the chemical formula C6H4BClF2COOH. The following is a description of its nature, use, preparation and safety information:

Nature:
4-Chloro-3-fluorophenylboronic acid is a colorless or pale yellow crystal with low solubility. It is an acidic compound, soluble in organic solvents such as ethanol and dimethyl ketone, but insoluble in water.

Use:
4-Chloro-3-fluorophenylboronic acid is often used as a catalyst in organic synthesis reactions, especially in Suzuki coupling reactions. It can catalyze the coupling reaction between boronic acids of aromatic compounds and organic halides to form new carbon-carbon bonds. This reaction is widely used in the fields of drug synthesis, material chemistry and pesticide synthesis.

Preparation Method:
4-Chloro-3-fluorophenylboronic acid can be obtained by reacting phenylboronic acid with chlorofluoroalkane. The specific synthesis method can be adjusted according to the laboratory conditions and the desired yield.

Safety Information:
When using 4-chloro-3-fluorophenylboronic acid, it is necessary to pay attention to safe operation. Because it is an irritant substance, it may cause irritation to the eyes, skin and respiratory tract. Wear appropriate protective gloves, glasses and a protective mask during use. During storage and handling, contact with oxidizing agents and strong acids should be avoided to prevent accidents. When accidentally touching the skin or eyes, rinse immediately with plenty of water and seek medical help. During handling and storage, please refer to the relevant safety data sheets and operating manuals to ensure safety.

Last Update：2024-04-09 19:05:46