137568-37-7
(R)-(-)-1,1'-Bi-2-naphthyl di-p-toluenesulfonate
CAS: 137568-37-7
Molecular Formula: C34H26O6S2
137568-37-7 - Names and Identifiers
| Name | (R)-(-)-1,1'-Bi-2-naphthyl di-p-toluenesulfonate |
| Synonyms | (R)-(-)-1,1'-BI-2-NAPHTHOL DITOSYLATE (R)-(-)-1,1'-BI-2-NAPHTHYL DITOSYLATE (S)-(+)-1,1'-BI-2-NAPHTHOL DITOSYLATE (R)-(-)-1,1'-Bi-2-naphthyl di-p-toluenesulfonate (R)-(-)-1,1'-BI-2-NAPHTHYL DI-P-TOLUENESULFONATE (R)-(+)-1,1'-BI-2-NAPHTHYL DI-P-TOLUENESULFONATE (S)-(+)-2,2'-BIS(P-TOLUENESULFONYLOXY)-1,1'-BINAPHTHYL (R)-(-)-2,2'-BIS(P-TOLUENESULFONYLOXY)-1,1'-BINAPHTHYL (R)-(-)-2,2-Bis-(p-toluenesulfonyloxy)-1,1-binaphthalene |
| CAS | 137568-37-7 |
| InChI | InChI=1/C20H14.2C7H8O3S/c1-3-11-17-15(7-1)9-5-13-19(17)20-14-6-10-16-8-2-4-12-18(16)20;2*1-6-2-4-7(5-3-6)11(8,9)10/h1-14H;2*2-5H,1H3,(H,8,9,10) |
137568-37-7 - Physico-chemical Properties
| Molecular Formula | C34H26O6S2 |
| Molar Mass | 594.7 |
| Density | 1.1898 (rough estimate) |
| Melting Point | 176-180°C(lit.) |
| Boling Point | 617.35°C (rough estimate) |
| Specific Rotation(α) | -34.5 º (c=1, CHCl3, 589nm) |
| Flash Point | 442.5°C |
| Water Solubility | Insoluble |
| Vapor Presure | 1.4E-27mmHg at 25°C |
| Refractive Index | 1.6950 (estimate) |
137568-37-7 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
137568-37-7 - Introduction
(R)-(-)-binaphthol di-p-toluenesulfonate, chemical formula C20H18O5S, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
(R)-(-)-binaphthol di-p-toluenesulfonate is a white solid. It has a melting point of 115-116°C and is soluble in most organic solvents, such as ethanol, acetone and dimethylformamide. This compound is chiral and exists only in optical isomers.
Use:
(R)-(-)-binaphthol di-p-toluenesulfonate is mainly used as a chiral reagent or catalyst. It is often used in organic synthesis as a chiral inducer, with a symmetrical di-substituted binaphthalene structure, which can provide stereo-guidance in chiral catalytic reactions. In addition, the compounds can also be used to prepare other organic compounds, such as chiral drug molecules.
Preparation Method:
The synthesis of (R)-(-)-binaphthol di-p-toluenesulfonate is generally obtained by esterification of binaphthol. A common method involves the esterification of p-binaphthol with p-cresol sulfonic acid using an acid chloride catalyst, such as p-methylbenzenesulfonyl chloride. Under appropriate reaction conditions, (R)-(-)-binaphthol ditosylate chiral products can be obtained.
Safety Information:
(R)-(-)-binaphthol di-p-toluenesulfonate is considered to be relatively safe under general conditions of use. However, it is still a chemical that requires proper safe handling. During use, wear appropriate personal protective equipment, such as laboratory gloves and protective glasses. At the same time, avoid contact with skin and eyes, such as contact, please rinse with plenty of water, and seek medical help. During storage and handling, keep away from flammable substances and strong oxidants to avoid fire and explosion accidents. Disposal must be carried out in accordance with proper chemical waste disposal procedures. In all cases, it is important to carefully read and comply with the safety data sheet of the compound.
Nature:
(R)-(-)-binaphthol di-p-toluenesulfonate is a white solid. It has a melting point of 115-116°C and is soluble in most organic solvents, such as ethanol, acetone and dimethylformamide. This compound is chiral and exists only in optical isomers.
Use:
(R)-(-)-binaphthol di-p-toluenesulfonate is mainly used as a chiral reagent or catalyst. It is often used in organic synthesis as a chiral inducer, with a symmetrical di-substituted binaphthalene structure, which can provide stereo-guidance in chiral catalytic reactions. In addition, the compounds can also be used to prepare other organic compounds, such as chiral drug molecules.
Preparation Method:
The synthesis of (R)-(-)-binaphthol di-p-toluenesulfonate is generally obtained by esterification of binaphthol. A common method involves the esterification of p-binaphthol with p-cresol sulfonic acid using an acid chloride catalyst, such as p-methylbenzenesulfonyl chloride. Under appropriate reaction conditions, (R)-(-)-binaphthol ditosylate chiral products can be obtained.
Safety Information:
(R)-(-)-binaphthol di-p-toluenesulfonate is considered to be relatively safe under general conditions of use. However, it is still a chemical that requires proper safe handling. During use, wear appropriate personal protective equipment, such as laboratory gloves and protective glasses. At the same time, avoid contact with skin and eyes, such as contact, please rinse with plenty of water, and seek medical help. During storage and handling, keep away from flammable substances and strong oxidants to avoid fire and explosion accidents. Disposal must be carried out in accordance with proper chemical waste disposal procedures. In all cases, it is important to carefully read and comply with the safety data sheet of the compound.
Last Update：2024-04-09 20:45:29
