13796-49-1

13796-49-1 - Names and Identifiers

Name	9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
Synonyms	9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate 9-Bromo-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione 21-Acetate 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-bromo-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
CAS	13796-49-1

13796-49-1 - Physico-chemical Properties

Molecular Formula	C24H31BrO6
Molar Mass	495.4
Physical and Chemical Properties	Chemical properties crystallization.
Use	Use an intermediate of dexamethasone acetate.

13796-49-1 - Production method

You can use 3 β-hydroxygestrol 5,16-dien-20ke-3-acetate (ie gestational dienolone acetate) via (16-position double bond and methyl nitrosourea) Addition and elimination (introduction of 16-methyl), (16-position double bond) epoxidation, (3-position hydroxyl) acetylation, (epoxy) ring opening, formation of 3 β,17 α-dihydroxy -16 β-methylpregnant-5, 15-diene -20-keto -3-acetate, and then (15-position double bond) catalytic hydrogenation, hydrolysis (removal of 3-position acetyl), oxidation (formation of 3-position ketone group, 4,5-position double bond), (21-position) iodination, (iodine atom is replaced by acetoxy), biological oxidation (to generate 11 α-hydroxyl), (11 α-hydroxyl) sulfonylation and elimination (to produce 9,11-double bond), dehydrogenation (to produce 1-position double bond), 9(11)-position double bond bromic acid addition to prepare the product.

Last Update：2024-04-10 22:29:15