138605-00-2

Name	N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE
Synonyms	NKH477 Colforsin dapropate NKH477 (hydrochloride) VIRRLEDAYYYTOD-YHEOSNBFSA-N 6-[3-(dimethylamino)propionyl]-forskolin y-3,4a,7,7,10a-pentamethyl-1-oxo-1h-naphtho(2,1-b)pyran-6-ylester,hydrochlor N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester beta-alanine hydrochloride
CAS	138605-00-2

Molecular Formula	C27H44ClNO8
Molar Mass	546.09
Solubility	H2O: soluble3mg/mL, clear to slightly hazy (warmed)
Appearance	White solid
Color	white to beige
Storage Condition	2-8°C
In vivo study	NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner. Animal Model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g Dosage: 1, 2 or 3 mg/kg/day Administration: Orally; daily; Days 3 and 5 Result: Prolonged lung allograft survival in a dose dependent manner.

Hazard Symbols	T+ - Very toxic
Risk Codes	28 - Very Toxic if swallowed
Safety Description	S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1 / PGII
WGK Germany	3
RTECS	AY5992600

biological activity	NKH477 (Colforsin dapropate hydrochloride) is a new type of water-soluble hair larynx derivative, which mainly improves heart failure through its beneficial effect on diastolic heart function. NKH477 directly activates the catalytic unit of adenylate cyclase (adenylate cyclase) and increases intracellular cAMP. The antiproliferative effect of NKH477 in vivo can inhibit the acute rejection of rat in situ lung allografts.
target	Adenylate Cyclase
in vivo study		NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner. Animal Model: Specific-pathogen-free inbredmale Lewis rats (LEW) weighing 250 to 280 g Dosage: 1, 2 or 3 mg/kg/day Administration: Orally; Daily; Days 3 and 5 Result: prolonged lung allograft survival in a dose dependent banner.
Animal Model:	Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g
Dosage:	1, 2 or 3 mg/kg/day
Administration:	Orally; daily; Days 3 and 5
Result:	Prolonged lung allograft survival in a dose dependent manner.