138883

138883 - Names and Identifiers

Name	1-BOC-3-METHANESULFONYLOXYPYRROLIDINE
Synonyms	138883 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE (R)-3-(Methylsulphonyloxy)pyrrolidine (R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected 1-(tert-Butoxycarbonyl)pyrrolidin-3-yl methanesulfonate 2-(3-pyrrolidinyloxysulfonyl)acetic acid tert-butyl ester tert-butyl 3-[(methylsulfonyl)oxy]pyrrolidine-1-carboxylate 3-METHANESULFONYLOXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS	141699-57-2
InChI	InChI=1/C10H19NO5S/c1-10(2,3)15-9(12)11-6-5-8(7-11)16-17(4,13)14/h8H,5-7H2,1-4H3

138883 - Physico-chemical Properties

Molecular Formula	C10H19NO5S
Molar Mass	265.33
Density	1.25±0.1 g/cm3(Predicted)
Boling Point	392.9±31.0 °C(Predicted)
Flash Point	191.4°C
Vapor Presure	2.22E-06mmHg at 25°C
pKa	-3.65±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.501

138883 - Risk and Safety

Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany	3
Hazard Class	IRRITANT

138883 - Introduction

N-Boc-3-methanesulfonyloxypyrrolidine is an organic compound. Its chemical structure contains a N-Boc group (tert-butoxycarbonyl) and a methanesulfonyloxy group. The following is a description of the properties, use, preparation and safety information of the compound:

Nature:
N-Boc-3-methanesulfonyloxypyrrolidine is a solid, usually white crystalline. It is stable at room temperature, but decomposes when heated. The compound has good solubility and can be dissolved in many organic solvents, such as dimethyl sulfoxide (DMSO) and methylene chloride.

Use:
N-Boc-3-methanesulfonyloxypyrrolidine is one of the reagents widely used to protect amino groups in the synthesis of organic compounds. By reacting with the amino group, it can form a protecting acyl group to protect the reactivity on the amino group. In organic synthesis, it is often used as a reagent in the synthesis of drugs, natural products, heterocyclic synthesis and the synthesis of chiral compounds.

Preparation Method:
The preparation of N-Boc-3-methanesulfonyloxypyrrolidine is generally carried out by the following reactions: first, reacting pyrrolidine with methylamine to obtain 3-methylaminopyrrolidine; then, reacting 3-methylaminopyrrolidine with N-Boc anhydride to obtain N-Boc-3-methylaminopyrrolidine; and finally, reacting methanesulfonic acid to obtain N-Boc-3-methanesulfonyloxypyrrolidine.

Safety Information:
N-Boc-3-methylsulfonyloxypyrrolidine needs to be operated in a well-ventilated place to avoid inhaling dust. Appropriate personal protective equipment, such as gloves, glasses and protective masks, should be worn during operation. Avoid direct contact with skin and eyes. If there is contact, rinse immediately with plenty of water. The compound should be kept away from fire and high temperatures during storage and use to prevent the risk of combustion and explosion.

Last Update：2024-04-09 21:01:54