13924-94-2

13924-94-2 - Names and Identifiers

Name	methyl 5-aminopyrazine-2-carboxylate
Synonyms	LogP 5-amino-pyrazine-2-carbox... Methyl 2-amino-5-pyrazinecarboxylate Methyl 5-aminopyrazine-2-carboxylate methyl 5-aminopyrazine-2-carboxylate Methyl 5-Aminopyrazine-2-carboxylate 5-Aminopyrazine-2-carboxylic acid methyl ester 5-Aminopyrazine-2-Carboxylic Acid Methyl Ester 5-AMino-2-pyrazinecarboxylic Acid Methyl Ester 2-Pyrazinecarboxylic acid, 5-amino-, methyl ester 5-aMinopyrazine-2-carboxylic acid Methyl ester HCl 5-aMino-pyrazine-2-carboxylic acid Methyl ester hydrochloride
CAS	13924-94-2
InChI	InChI=1/C6H7N3O2/c1-11-6(10)4-2-9-5(7)3-8-4/h2-3H,1H3,(H2,7,9)

13924-94-2 - Physico-chemical Properties

Molecular Formula	C6H7N3O2
Molar Mass	153.14
Density	1.319
Melting Point	230-232?C
Boling Point	363℃
Flash Point	173℃
Vapor Presure	0mmHg at 25°C
Storage Condition	Keep in dark place,Sealed in dry,2-8°C
Refractive Index	1.577

13924-94-2 - Reference Information

Introduction

Methyl 5-aminopyrazine-2-formate is a class of important organic intermediates, which can be made of 5-halopyrazine-2-formate. The raw material reacts with substituted amino reagents to form 5-substituted aminopyrazine-2-formate, 5-substituted aminopyrazine-2-formate deamination protection group and then hydrolysis of the ester to produce.

Preparation

1.5-aminopyrazine-2-methyl formate synthesis process, which is characterized in that it is prepared by the following synthesis steps: 5-halopyrazine-2-formate is used as raw material to react with substituted amininating reagents to generate 5-substituted aminopyrazine-2-formate, 5-substituted aminopyrazine-2-formate deamination protecting group and then hydrolysis of the ester to produce 5-aminopyrazine-2-formate; the specific steps are as follows:(1) 5-halogenated pyrazine-2-formate is used as raw material and substituted amination reagent in the presence of organic solvent and alkali Reacts at 60-70 ℃, after the reaction, the reaction liquid is poured into water, filter and dry to obtain methyl 5-aminopyrazine-2-formate, wherein X is any one of F,Cl,Br,l; wherein R is any one of methyl, ethyl, and isopropyl; R2 is any one of p-methoxybenzylamine or tert-butylamine; the molar ratio of the alkali to 5-halopyrazine-2-formate is 1.1:1; the molar ratio of the substituted aminidation reagent to 5-halopyrazine-2-formate is 1.5-2.0: 1;(2)5-substituted aminopyrazine-2-formate refluxing under the action of acid to generate an acid salt corresponding to methyl 5-aminopyrazine-2-formate, the acid is trifluoroacetic acid, hydrochloric acid, any one of hydrobromic acid; (3) 5-aminopyrazine-2-formic acid is used as an acid salt of 5-aminopyrazine-2-formate in the action of alkali to obtain 5-aminopyrazine-2-formic acid. The alkali is sodium hydroxide, and the molar ratio of sodium hydroxide to 5-aminopyrazine-2-formate is 2-3:1.

Last Update：2024-04-09 21:04:16