139298-40-1
KN-93
CAS: 139298-40-1
Molecular Formula: C26H29ClN2O4S
139298-40-1 - Names and Identifiers
| Name | KN-93 |
| Synonyms | KN-93 KN-93, WATER-SOLUBLE METHOXYBENZENE-SULFONAMIDE 2-[N-(2-HYDROXYETHYL)-N-(4-METHOXYBENZENESULFONYL)]AMINO-N-(4-CHLOROCINNAMYL)-N-METHYLBENZYLAMINE N-[2-N-4-CHLOROCINNAMYL-N-METHYLAMINOMETHYLPHENYL]-N-[2-HYDROXYETHYL]-4-METHOXYBENZENESULFONAMIDE N-[2-[[[3-(4-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULPHONAMIDE N-[2-[[[3-(4'-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4'-METHOXY-BENZENESULFONAMIDE PHOSPHATE |
| CAS | 139298-40-1 |
| InChIKey | LLLQTDSSHZREGW-AATRIKPKSA-N |
139298-40-1 - Physico-chemical Properties
| Molecular Formula | C26H29ClN2O4S |
| Molar Mass | 501.04 |
| Density | 1.288 |
| Solubility | DMSO: 1mg/mL |
| Appearance | Off-white solid |
| Color | white |
| Storage Condition | 2-8°C |
| In vitro study | After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. KN-93 (10 μM )significantly inhibits the activation of CaMKII/NF-κB signaling induced by elevated glucose, and subsequently decreases the expression of VEGF, iNOS and ICAM-1 in Müller cells. |
| In vivo study | KN-93 (1 mg/kg/day, i.p.) inhibits retinal vascular leakage induced by diabetes, and suppresses phosphorylation of CaMKII and NF-κB in diabetic retina. |
139298-40-1 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29299000 |
139298-40-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.996 ml | 9.979 ml | 19.958 ml |
| 5 mM | 0.399 ml | 1.996 ml | 3.992 ml |
| 10 mM | 0.2 ml | 0.998 ml | 1.996 ml |
| 5 mM | 0.04 ml | 0.2 ml | 0.399 ml |
Last Update：2024-01-02 23:10:35
139298-40-1 - Reference Information
| biological activity | KN-93 is a cell-permeable and competitive Ca2 /calmodulin-dependent protein kinase II (CaMK-II) the Ki value of the reversible inhibitor of CaM Kinase activity for rabbit myocardium was 2.58 μm. |
| Target | Value |
| CaMKII (Cell-free assay) | 2.58 μM(Ki) |
Last Update：2024-04-09 21:54:55
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Mobile: 18021002903
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