139667-74-6

Name	CGP 52432
Synonyms	P52432 CGP-52432 CGP 52432 (3-((3,4-dichlorobenzyl)amino)propyl)(diethoxymethyl)phosphinic acid 3-([[[(3,4-DICHLOROPHENYL)METHYL]AMINO]PROPYL] DIETHOXYMETHYL)PHOSPHINIC ACID Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)-
CAS	139667-74-6
EINECS	000-000-0

Molecular Formula	C15H24Cl2NO4P
Molar Mass	384.24
Density	1.258±0.06 g/cm3(Predicted)
Boling Point	544.4±50.0 °C(Predicted)
Solubility	H2O: soluble1mg/mL, clear (warmed)
Appearance	powder
Color	white to beige
pKa	2.26±0.50(Predicted)
Storage Condition	2-8°C
In vitro study	CGP52432 is a GABA B receptor antagonist, with an IC 50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.
In vivo study	CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	CGP52432 is a potent selective antagonist of GABAB autoreceptor with an IC50 value of 0.085 μm.
Target	Value
GABA B autoreceptor (Cell-free assay)	0.085 μM

Last Update：2024-04-10 22:29:15

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139667-74-6

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