14-Deoxy-11,12-didehydroandrographolide
14-Deoxy-11,12-didehydroandrographolide
CAS: 42895-58-9
Molecular Formula: C20H28O4
14-Deoxy-11,12-didehydroandrographolide - Names and Identifiers
14-Deoxy-11,12-didehydroandrographolide - Physico-chemical Properties
| Molecular Formula | C20H28O4 |
| Molar Mass | 332.43 |
| Density | 1.17 |
| Melting Point | 204-205℃ |
| Boling Point | 519.6±50.0 °C(Predicted) |
| Specific Rotation(α) | +5.4 (c, 1.02 in MeOH) |
| Appearance | neat |
| pKa | 14.80±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | 14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity. |
| In vivo study | 14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine. |
14-Deoxy-11,12-didehydroandrographolide - Risk and Safety
| WGK Germany | 3 |
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