1401708-83-5

Name	Dihexa
Synonyms	amide Dihexa PNB-0408 aminohexanoic Dihexa (PNB-0408) N-hexanoic-Tyr-Ile-(6) Hexanoyl-Tyr-Ile-Ahx-NH2 TIANFUCHEM--1401708-83-5---Dihexa N-hexanoic-Try-Ile-(6)-amino hexanoic amide N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-
CAS	1401708-83-5
EINECS	227-005-2

Molecular Formula	C27H44N4O5
Molar Mass	504.66
Density	1.111±0.06 g/cm3(Predicted)
Melting Point	>209°C (dec.)
Boling Point	866.2±65.0 °C(Predicted)
Solubility	DMSO: ≥ 30 mg/mL
Appearance	Solid
Color	White to Off-White
pKa	9.83±0.15(Predicted)
Storage Condition	Hygroscopic, Refrigerator, under inert atmosphere
Physical and Chemical Properties	Appearance: white powder
Use	Sequence: Hexanoyl-Tyr-Ile-Ahx-NH2
In vitro study	Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met.
In vivo study	Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons.

Last Update：2024-01-02 23:10:35

Biological activity	Dihexa (PNB-0408), an oligopeptide reagent, is an angiotensin IV analog with oral activity and permeability of the blood-brain barrier. Dihexa binds hepatocyte growth factor (HGF) with high affinity with a Kd value of 65 pM and enhances its activity against receptor c-Met. Dihexa showed excellent antipsychotic activity and improved cognitive function in animal models. Dihexa has the potential to study Alzheimer's.
target	Kd: 65 pM (HGF)
in vitro study	dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV inuce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met.
in vivo study	Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons.

Last Update：2024-04-09 21:54:55

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Product Name: Dihexa Visit Supplier Webpage Request for quotation
CAS: 1401708-83-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Dihexa Request for quotation
CAS: 1401708-83-5
Tel: 008655165326643
Email: qilin@cellmano.com
Mobile: 008618156095617
QQ: 1761863581

Send QQ message

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1401708-83-5

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