140645-23-4
(R)-N-Boc-3-aminomethylpiperidine
CAS: 140645-23-4
Molecular Formula: C11H22N2O2
140645-23-4 - Names and Identifiers
140645-23-4 - Physico-chemical Properties
| Molecular Formula | C11H22N2O2 |
| Molar Mass | 214.3 |
| Density | 0.997g/mLat 25℃ |
| Boling Point | 299.4±13.0 °C(Predicted) |
| Flash Point | >110°C |
| Vapor Presure | 0.001mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to pale yellow |
| pKa | 10.12±0.29(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.473 |
140645-23-4 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R50 - Very Toxic to aquatic organisms R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3082 9 / PGIII |
| WGK Germany | 3 |
140645-23-4 - Reference Information
| Use | (R)-1-boc-3-aminomethylpiperidine is an important intermediate for the synthesis of many drugs. A series of Checkpoint Kinase 1 (CHK1) inhibitors were synthesized with (R)-1-boc-3-aminomethylpiperidine as raw material; using this compound as raw material, a series of drugs for treating related diseases caused by MCH (Melanin-concentrating hormone) were synthesized, which also had certain effects on treating metabolic disorders; G-protein coupled receptor (GPCR) agonists containing 1-n-boc-4-methylaminomethylpiperidine building blocks were synthesized and used in the treatment of obesity and diabetes; (R)-1-boc-3-aminomethylpiperidine synthesizes a series of drugs for regulating metabolism and treating cardiovascular diseases. |
| preparation | 3-piperidineacetic acid as raw material, through esterification, reduction, tert-butoxycarbonyl protection, bromination, an important drug intermediate, 1-boc-3-aminomethylpiperidine, was synthesized with a total yield of 72% by the five-step reaction of methylamine, and then (R)-1-boc-3-aminomethylpiperidine was prepared by chiral resolution. The synthesis route is as follows: Figure 1 (R)-1-boc-3-aminomethylpiperidine synthesis route |
Last Update：2024-04-09 15:16:40
