141625-93-6
Dronedarone hydrochloride
CAS: 141625-93-6
Molecular Formula: C31H44N2O5S.ClH
141625-93-6 - Names and Identifiers
| Name | Dronedarone hydrochloride |
| Synonyms | CS-132 Multaq SR-33589B Dronedarone HCl Dronedarone hydrochloride Dronedarone Hydrocholoride Dronedarone Intermediate 1 N-[2-butyl-3-[4-(3-dibutyl-aminopropoxy) benzoyl] methanesulfonamide hydrochloride N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-benzofuran-5-yl)methanesulfonamide hydrochlorid |
| CAS | 141625-93-6 |
| EINECS | 630-355-2 |
| InChI | InChI=1/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H |
| InChIKey | DWKVCQXJYURSIQ-UHFFFAOYSA-N |
141625-93-6 - Physico-chemical Properties
| Molecular Formula | C31H44N2O5S.ClH |
| Molar Mass | 593.224 |
| Melting Point | NA (low-melting) |
| Boling Point | 683.9°C at 760 mmHg |
| Flash Point | 367.4°C |
| Solubility | DMSO: soluble15mg/mL, clear |
| Vapor Presure | 1.47E-18mmHg at 25°C |
| Appearance | White to white-like powder |
| Color | white to off-white |
| Merck | 14,3449 |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| MDL | MFCD00914940 |
| In vitro study | In Purkinje fibers, Dronedarone decreased the early and delayed depolarization induced by 1 mM Dofetilide and 0.2 mM Strophantidine. In ventricular myocytes, Dronedarone(10 mM) significantly reduced L-type calcium currents (76.5%) and delayed rectifier potassium currents (97%). [1] In single cells isolated from the sinoatrial node (SAN) of the Rabbit Heart, Dronedarone inhibits I(K(ACh)) by reducing the channel opening probability (from 0.56 to 0.11) channel cell attachment without changing the single channel conductance. [2] In guinea pig ventricular myocytes, when the holding potential is -80 mV, Dronedarone state-dependent inhibition of fast Na(+) channel current, IC50 is 0.7 μm. At, Dronedarone blocked the -40 mV rectangular pulse-induced calcium ion current with an IC50 value of 0.4 μm, while at a holding potential of -80 mV, Dronedarone (10 μm) only 20% of the current is blocked. [3] |
| In vivo study | In the rat normal heart, Dronedarone increases the action potential duration. Dronedarone reduces the late sustained K() current, I(K)(or ISUS) by 69%. Dronedarone induced tonic blockade of I(K). In rats with myocardial infarction, Dronedarone induced a weak increase in fast transient outward currents. [4] |
141625-93-6 - Risk and Safety
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 2935904000 |
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Spot supply
Product Name: Dronedarone HCl Visit Supplier Webpage Request for quotationCAS: 141625-93-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Dronedarone Hydrochloride Visit Supplier Webpage Request for quotationCAS: 141625-93-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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