14176-50-2
TILETAMINE HYDROCHLORIDE
CAS: 14176-50-2
Molecular Formula: C12H18ClNOS
14176-50-2 - Names and Identifiers
14176-50-2 - Physico-chemical Properties
| Molecular Formula | C12H18ClNOS |
| Molar Mass | 259.79 |
| Melting Point | 186-188°C (dec.) |
| Solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Refrigerator, Under Inert Atmosphere |
| Use | Tiletamine hydrochloride is a white powder substance, mainly used for block anesthesia and general anesthesia. |
14176-50-2 - Risk and Safety
| HS Code | 2934990002 |
14176-50-2 - Instructions for Injection Tetamine Hydrochloride Zolazepam Hydrochloride
Open Data Unverified Data
[name of veterinary drug]
Common name: Tilestamine Hydrochloride for Injection Zolazepam Hydrochloride
[main ingredients] tiletamine hydrochloride, zolazepam hydrochloride
[properties] this product is white to light yellow crystalline frozen powder.
[pharmacological action] pharmacodynamics this product is a compound anesthetic. The mechanism of action of teletamide hydrochloride and zolazepam hydrochloride can complement each other. Tiletamine is a separate anesthetic, its pharmacological effects are similar to ketamine; Zolazepam is a benzodiazepine? Class sedative hypnotics, pharmacological effects are similar to diazepam, with anti-anxiety, sedation, anticonvulsant and muscle relaxation effects. Zolazepam can strengthen the inhibitory effect of teeltamine on the central nervous system, while preventing convulsions caused by teeltamine, enhancing muscle relaxation effects, and shortening the recovery time from anesthesia. This product can quickly relax muscles, causing superficial pain and visceral pain to disappear, and does not cause respiratory central depression. It has sedative, analgesic and anesthetic effects.
after intramuscular injection of 10mg/kg body weight in dogs and cats, the blood drug concentration of leitamin and zolaixiyang reached a peak within 30 minutes. The duration of anesthesia was 20 to 60 minutes. The half-life of timutamine: 75 minutes for dogs and 150 minutes for cats; the half-life of Zolafan: 60 minutes, 270 minutes for cats.
Drug interactions
1. Combination with phenothiazines (acepromazine, chlorpromazine) can increase the risk of cardiac depression, respiratory depression and hypothermia.
2. Chloramphenicol will reduce the metabolic rate of anesthetics.
[indication] is used for Baoding and general anesthesia in dogs and cats.
[usage and dosage] dissolve the powder in the solid bottle with sterile water for injection in the package before use.
Preoperative medication: use atropine sulfate 15 minutes before injection of this product,
subcutaneous injection: 0.1mg for dogs and 0.05mg for cats per 1kg of body weight.
general anesthesia: first dose, intramuscular injection: 7~25mg per 1kg body weight for dogs. Cats 10~15mg. Or intravenous injection: 5~10mg for dogs and 5~7.5mg for cats per 1kg of body weight.
maintenance dose: 1/3~1/2 of the first dose, preferably intravenous injection.
[Adverse reactions] Like other anesthetics, possible adverse reactions during use are related to the health status, age, dosage and duration of the individual animal. Possible adverse reactions include:
- Induction syndrome: such as cardiopulmonary failure, increased tracheal secretion, vomiting, etc.
- Post-anesthesia syndrome: such as prolonged awakening time, thermoregulation disorder, gastric dilatation, etc.
- allergic reaction.
[Contraindications]
- Dogs and cats receiving systemic organophosphate carbamate insecticidal treatment.
- Dogs and cats with severe heart disease or respiratory defects.
- Animals with pancreatic defects.
- cats with severe hypertension.
[Precautions]
- use under veterinary guidance
- fasting for 12 hours before anesthesia.
- Make sure dogs and cats wake up in a quiet and cool environment.
- Pay attention to keep dogs and cats warm to prevent excessive heat loss.
- after the crystal is diluted, it can be stored at room temperature for 48 hours away from light or 2 ~ 8C away from light for 8 days
Last Update：2024-04-09 21:40:26
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