1425973-16-5
Azido-PEG5-acid
CAS: 1425973-16-5
Molecular Formula: C13H25N3O7
1425973-16-5 - Names and Identifiers
1425973-16-5 - Physico-chemical Properties
| Molecular Formula | C13H25N3O7 |
| Molar Mass | 335.36 |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
1425973-16-5 - References
| biological activity | Azido-PEG3-acid is a PROTAC linker belonging to the PEG class. Mal-PEG1-acid can be used for the synthesis of PROTAC molecules. For example, a CPT-APO (CPT: Camptothecin (HY-16560)) conjugate was synthesized. Azido-PEG3-acid is a non-cleavable ADC linker containing 5 units of PEG, which can be used to synthesize antibody conjugated drugs (ADC). |
Last Update：2024-04-10 22:29:15
