143-67-9
Vinblastine sulfate
CAS: 143-67-9
Molecular Formula: C46H60N4O13S
143-67-9 - Names and Identifiers
| Name | Vinblastine sulfate |
| Synonyms | exal velbe velban 29060le nsc49842 rozevinsulfate Vinblastin Sulfate Vinblastine sulfate vinblastine sulphate Vinblastine sulfate salt Vinblastine, sulphate salt vincaleukoblastine sulfate salt (2alpha,3alpha,4alpha,5beta,19beta)-vincaleukoblastine (2alpha,2'beta,3alpha,4alpha,5beta,19beta)-vincaleukoblastine (2alpha,3alpha,4alpha,5beta,19beta)-vincaleukoblastine sulfate (2alpha,2'beta,3alpha,4alpha,5beta,19beta)-vincaleukoblastine sulfate |
| CAS | 143-67-9 |
| EINECS | 205-606-0 |
| InChI | InChI=1/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28?,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1 |
| InChIKey | KDQAABAKXDWYSZ-PNYVAJAMSA-N |
143-67-9 - Physico-chemical Properties
| Molecular Formula | C46H60N4O13S |
| Molar Mass | 909.05 |
| Melting Point | 267°C (dec.)(lit.) |
| Specific Rotation(α) | -21.7 º (c=2, CH3OH 21 ºC) |
| Water Solubility | >=1 g/100 mL at 24.5 ºC |
| Solubility | Easily soluble in water, insoluble in organic solvents such as petroleum ether and chloroform. |
| Appearance | White crystal |
| Color | white |
| Merck | 13,10044 |
| BRN | 3659812 |
| PH | 3.5～5.0 (1g/l, 25℃) |
| Storage Condition | 2-8°C |
| MDL | MFCD00082457 |
| Physical and Chemical Properties | Melting point 267°C specific optical rotation -21.7 ° (c = 2, CH3OH 21°C) water-soluble> = 1g/100 mL at 24.5°C |
| Use | Antineoplastic drugs for the treatment of Hodgkin's disease and choriocarcinoma, lymphosarcoma, acute leukemia, breast cancer and other certain curative effect |
143-67-9 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R61 - May cause harm to the unborn child R36/37/38 - Irritating to eyes, respiratory system and skin. R63 - Possible risk of harm to the unborn child R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | YY8400000 |
| FLUKA BRAND F CODES | 8-10 |
| HS Code | 29399990 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 i.v. in mice: 9.5 mg/kg (Lu, Meistrich) |
143-67-9 - Reference
| Reference Show more | 1. Li Lu, An Ye Juan, Qiao Chunlei, et al. Ultrasonic-microwave synergistic extraction of epimedium alkaloids and its inhibitory effect on HeLa cells [J]. Acta Botanica Sinica, 2018, 053(003):341-352. |
143-67-9 - Reference Information
| (IARC) carcinogen classification | 3 (Vol. 26, Sup 7) 1987 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | Vinblastine sulfate (VinblastineSulfate) is a national essential drug, mainly suitable for the treatment of Hokkikin's disease and malignant lymphoma, and can also be used for the treatment of chorioepithelial cancer and breast cancer. It can also be used for bronchial lung cancer, soft tissue sarcoma, testicular tumor, ovarian cancer, digestive tract cancer, malignant circulating melanoma and neuroblastoma, etc, it is one of the most widely used natural plant anticancer drugs in the world. A natural alkaloid isolated from the plant Catharanthus roseus, which binds to tubulin and inhibits the formation of microtubules, leading to the division of mitotic spindles and the arrest of tumor cells in the M phase of the cell cycle. Anti-tumor drugs are used to treat Hodgkin's disease and chorioepithelial carcinoma. They also have certain curative effects on lymphosarcoma, acute leukemia, breast cancer, etc. Anti-tumor drugs are used for malignant lymphoma. |
| pharmacological action | this strain is an alkaloid proposed from periwinkle, a plant of Apocynaceae. it is a cell cycle specific antitumor drug, acts on G1, s and m phases, and has a delaying effect on m phase, can interfere with the formation of proliferating cell spindle and stop mitosis in the middle stage. At higher doses, it can directly destroy chromosomes, crystallize microtubule proteins, and prevent the assembly of microtubule proteins. In addition, there is an immunosuppressive effect. |
Last Update：2024-04-09 02:00:06
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Product Name: Vinblastine Sulfate Visit Supplier Webpage Request for quotationCAS: 143-67-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Vinblastine Sulfate Visit Supplier Webpage Request for quotationCAS: 143-67-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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