1433497-19-8

Name	LY2955303
Synonyms	CS-2631 LY2955303 LY 2955303 LY-2955303 4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic acid Benzoic acid, 4-[5-[3,5-bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-
CAS	1433497-19-8

Molecular Formula	C36H42N4O3
Molar Mass	578.74
Density	1.15±0.1 g/cm3(Predicted)
Boling Point	721.9±60.0 °C(Predicted)
pKa	3.84±0.10(Predicted)
Storage Condition	2-8°C
In vitro study	LY2955303 is tested and observed that the binding K i s for RARα, RARβ and RARγ are >1700, >2980 and 1.09 nM, respectively. The functional K i for RARγ is 7.1±4.9 nM.
In vivo study	A single oral dose of LY2955303 demonstrates a dose responsive effect whereby the rat reduces differential weight bearing (ED 50 =0.72 mg/kg).

biological activity	LY2955303 is a potent and selective antagonist of retinoic acid receptor gamma (RAR gamma), its Ki value is 1.09 nM.
Target	Ki: 1.09 nM (RAR γ)

Last Update：2024-04-09 15:16:58

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CAS: 1433497-19-8
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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1433497-19-8

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