144494-65-5
Tirofiban
CAS: 144494-65-5
Molecular Formula: C22H36N2O5S
144494-65-5 - Names and Identifiers
| Name | Tirofiban |
| Synonyms | C07965 MK-383 MK383 CS-584 L700462 Tirofiban Aggrastat TIROFIBAN AGGRASTAT N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine N-(butylsulfonyl)-O-[4-(piperidin-4-yl)butyl]-L-tyrosine (2s)-2-(butylsulfonylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propanoic acid |
| CAS | 144494-65-5 |
| EINECS | 635-682-4 |
| InChI | InChI=1/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1 |
144494-65-5 - Physico-chemical Properties
| Molecular Formula | C22H36N2O5S |
| Molar Mass | 440.6 |
| Density | 1.154±0.06 g/cm3(Predicted) |
| Melting Point | 223-225° |
| Boling Point | 611.7±65.0 °C(Predicted) |
| Flash Point | 323.7°C |
| Vapor Presure | 8.09E-16mmHg at 25°C |
| BRN | 6182267 |
| pKa | 3.37±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.531 |
| Physical and Chemical Properties | White solid, melting point 223~225 ℃. Tilofeba hydrochloride (Tirofiban Hydrochloride):C22H36N2O5S?HCl?H2O. [150915-40-5]. Solid, melting point 131~132 ℃. [α] D23-14.4 (C = 0.92, methanol). |
144494-65-5 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | YP2364100 |
144494-65-5 - Reference
| Reference Show more | 1. [IF=20.722] Huijuan Zhang et al."Shear force responsive and fixed-point separated system for targeted treatment of arterial thrombus."Nano Today. 2021 Jun;38:101186 |
144494-65-5 - Nature
Open Data Verified Data
white solid, melting point 223-225 °c.
Last Update：2024-01-02 23:10:35
144494-65-5 - Preparation Method
Open Data Verified Data
L-tyrosine, acetonitrile and N,O-bis (trimethylsilyl) trifluoromethylacetamide were mixed, refluxed, and pyridine and N-butylsulfonyl chloride were added. After completion of the reaction, N-N-butylsulfonyl-L-tyrosine was obtained by treatment. Tetrahydrofuran was mixed with 4-methylpyridine, and a solution of N-butyllithium in hexane was slowly added, which was then slowly added to a solution of 3-bromo-1-chloropropane in tetrahydrofuran. After completion of the reaction, 4-(4-pyridyl) butyl chloride hydrochloride was obtained. N-N-butylsulfonyl-l-tyrosine and 4-(4-pyridyl) butyl chloride hydrochloride obtained above were dissolved in dimethyl sulfoxide, and an aqueous solution of potassium hydroxide was added with vigorous stirring, further reaction with the addition of potassium iodide gives N-(N-butylsulfonyl)-O-[4-(4-pyridyl) butyl]-L-tyrosine. This and the Palladium-on-carbon catalyst were dissolved in acetic acid, and after hydrogenation, tirofiban was worked up. In isopropyl acetate, acidification with concentrated hydrochloric acid gave tirofiban hydrochloride.
Last Update：2022-01-01 09:10:25
144494-65-5 - Use
Open Data Verified Data
developed by Merck, USA, was first launched in the United States in 1998. Antithrombotic drugs. For the treatment of unstable angina. Specific non-peptide platelet fibrinogen receptor antagonists.
Last Update：2022-01-01 09:10:26
144494-65-5 - Introduction
Tirofiban, the chemical name 2,2-dibromoethoxyethane, is a colorless liquid. The following is a description of the nature, use, formulation and safety information of Tirofiban:
Nature:
-Appearance: Tirofiban is a colorless to pale yellow liquid.
-Density: about 1.98g/cm³.
-Boiling point: About 230 ℃.
-Melting point: About -100 ℃.
-Solubility: Soluble in water and many organic solvents.
Use:
- Tirofiban is mainly used as a reagent in organic synthesis, especially its ethanyltetramethylammonium salt (TREBA) is used as a quaternary ammonium salt catalyst for catalytic reactions.
-It can also be used in some chemical synthesis, such as alcohol etherification reaction, halogen reaction, etc.
Preparation Method:
- Tirofiban can be prepared by the reaction of 2-bromoethanol and hypobromoethane. The reaction proceeds with SN2 substitution, and hypobromoethane reacts as a nucleophile with 2-bromoethanol to give Tirofiban.
Safety Information:
- Tirofiban should be used in a well-ventilated area, avoiding inhalation and contact with skin.
-Wear protective gloves, goggles and protective clothing during operation to avoid inhaling vapors.
-Wash thoroughly after use and dispose of waste properly.
-In the event of accidental inhalation, contact or ingestion of Tirofiban, seek immediate medical assistance and bring the packaging container or label for your doctor's reference.
Nature:
-Appearance: Tirofiban is a colorless to pale yellow liquid.
-Density: about 1.98g/cm³.
-Boiling point: About 230 ℃.
-Melting point: About -100 ℃.
-Solubility: Soluble in water and many organic solvents.
Use:
- Tirofiban is mainly used as a reagent in organic synthesis, especially its ethanyltetramethylammonium salt (TREBA) is used as a quaternary ammonium salt catalyst for catalytic reactions.
-It can also be used in some chemical synthesis, such as alcohol etherification reaction, halogen reaction, etc.
Preparation Method:
- Tirofiban can be prepared by the reaction of 2-bromoethanol and hypobromoethane. The reaction proceeds with SN2 substitution, and hypobromoethane reacts as a nucleophile with 2-bromoethanol to give Tirofiban.
Safety Information:
- Tirofiban should be used in a well-ventilated area, avoiding inhalation and contact with skin.
-Wear protective gloves, goggles and protective clothing during operation to avoid inhaling vapors.
-Wash thoroughly after use and dispose of waste properly.
-In the event of accidental inhalation, contact or ingestion of Tirofiban, seek immediate medical assistance and bring the packaging container or label for your doctor's reference.
Last Update：2024-04-09 15:16:34
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Product Name: Tirofiban Visit Supplier Webpage Request for quotationCAS: 144494-65-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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