14459-29-1
HEMATOPORPHYRIN
CAS: 14459-29-1
Molecular Formula: C34H38N4O6
14459-29-1 - Names and Identifiers
14459-29-1 - Physico-chemical Properties
| Molecular Formula | C34H38N4O6 |
| Molar Mass | 598.69 |
| Density | 1.328 |
| Melting Point | 172.5°C |
| Boling Point | 649.58°C (rough estimate) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.6 |
| Physical and Chemical Properties | Chemical properties of red-purple crystals, soluble in ethanol, ether and chloroform-soluble, insoluble in water. |
| Use | Uses biochemical research, clinical for the treatment of cancer. |
14459-29-1 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
14459-29-1 - Reference
| Reference Show more | 1. Xue Rui, Ye Yang, Jingjing Wu, Jing Chen, Qingqing Chen, Rongrong Ren, Qingqing Zhang, Yingying Hu, Dengke Yin, Multi-path tumor inhibition via the interactive effects between tumor microenvironment and an oxygen self-supplying delivery system for a photos |
14459-29-1 - Basic research on photodynamic therapy for nevus flammeus -- Comparison of absorption characteristics between hematoxylin methyl ether and hematoporphyrin derivatives
from hownet
Author:
Liu fanguang , Gu Ying , Fu Qiu Tao , Yu-Ming Pan , Li Junheng ,LIUFanguang,GUYing,FUQiutao,PanYuming,LIJunheng
Abstract:
objective to observe the absorption characteristics of a new photosensitizer, hemoline methyl ether (HMME) in the skin tissue and vascular endothelial cells (EC) of chicken comb. Methods 12 chickens were divided into HMME group and hematoporphyrin derivative (HpD) group, 6 in each group. 10 mg/kg of HMME and 10 mg/kg of HpD were injected intravenously, and 2.5 ml of blood and 2.5g of comb skin tissue were collected every 10 min. Neonatal umbilical cord EC was cultured, and HMME or HpD was added to the culture medium. The incubation concentrations were 20,40,60,80 and 100 μg/ml, respectively, 60,120,180 and 240 min. The content of photosensitizer was determined by fluorescence analysis, and the concentration-content and time-content relationship curves of EC absorption photosensitizer were drawn. Results after intravenous injection of HMME or HpD, the peak value of serum concentration appeared at 10 min after injection, and then decreased rapidly with time, and the curve morphology of the two was basically the same. The content of HMME in the comb tissue 10 min after injection was significantly higher than that of HpD(P<0.01), however, it was still significantly higher than HpD at 8 0 min after injection (P<0.05). Cultured EC could rapidly absorb HMME and HpD, and reached more than 89% of the peak value in 30 min. The absorption amount of HMME was linear with the incubation concentration, and the absorption amount of HMME was significantly higher than that of HpD(P<0.01). Conclusion HMME is more easily taken up by EC in the microvessels of the skin than HpD, which is beneficial to the treatment of port wine stains.
stowed
Key words:
port wine stains vascular endothelial cells hematolinemethyl ether hematoporphyrin derivative photodynamic therapy treatment
DOI:
10.3969/j.issn.1003-9430.2001.01.003
cited:
year:
2001
Last Update：2024-01-02 23:10:35
14459-29-1 - Effects of cell types and incubation time on the distribution of hematoporphyrin monomethyl ether in cells
from Wanfang
Author:
Liu fanguang , David , Gu Ying , Wang Lei , Li Xiaosong , Zeng Jing
Abstract:
Objective to investigate the effects of cell types and incubation time on the intracellular distribution of hematoporphyrin monomethyl ether (HMME). Methods mouse lung endothelial cells (1H11) and A549 lung cancer cells were subcultured and incubated with photosensitizer HMME for 2 h and 12 h, respectively. The subcellular distribution of HMME under different conditions was studied by using high-resolution fluorescence microscopy imaging system composed of fluorescence microscope and CCD, combined with fluorescence probe labeling technology, and the organelle-cell fluorescence intensity ratio method. Results The J1/J2 values of Golgi apparatus were the highest at 2 h and 12 h incubation time points, the J1/J2 values of the four organelles of A549 cells were all increased and the lysosomal amplitude was the largest, while the J1/J2 values of lysosomes in mouse lung endothelial cells showed an increasing trend, the J1/J2 values of organelles such as endoplasmic reticulum and mitochondria showed a downward trend. The increase of J1/J2 values of lysosomes in A549 cells was significantly higher than that in rat lung endothelial cells. Conclusion The subcellular distribution of HMME is different in different cell types. The effect of incubation time on subcellular distribution of HMME was significant. With the extension of incubation time, the ability of A549 lung cancer cell organelles to absorb HMME gradually increased, especially in lysosomes. The ability of organelles to absorb HMME except lysosomes in mouse lung endothelial cells gradually decreased. After 12 h incubation, the ability of A549 lung cancer cells to absorb HMME was stronger than that of rat lung endothelial cells.stowed
Key words:
incubation time cell type hematoporphyrin monomethyl ether intracellular distribution
DOI:
CNKI:SUN:ZGJG.0.2005-03-009
cited:
year:
2005
Last Update：2023-08-16 22:05:47
14459-29-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.67 ml | 8.352 ml | 16.703 ml |
| 5 mM | 0.334 ml | 1.67 ml | 3.341 ml |
| 10 mM | 0.167 ml | 0.835 ml | 1.67 ml |
| 5 mM | 0.033 ml | 0.167 ml | 0.334 ml |
Last Update：2024-01-02 23:10:35
14459-29-1 - A preliminary study of ultrasound-activated hematoporphyrin killing S180 cancer cells
from VIP
Author:
Liu Quan-macro , Wang Zhonghui
Abstract:
Abstract:
Key words:
Ultrasound hematoporphyrin S180 cancer cells killing effect
cited:
year:
1994
Last Update：2023-08-16 22:05:47
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